Hepatic toxicity resulting from cancer treatment

Journal Article · Thu Mar 30 04:00:00 EST 1995 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/0360-3016(94)00418-K· OSTI ID:90886

Lawrence, T S; Robertson, J M ^[1]; Anscher, M S ^[2]

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1. Univ. of Michigan School of Medicine, Ann Arbor, MI (United States)
2. Duke Univ. School of Medicine, Durham, NC (United States); and others

Radiation-induced liver disease (RILD), often called radiation hepatitis, is a syndrome characterized by the development of anicteric ascites approximately 2 weeks to 4 months after hepatic irradiation. There has been a renewed interest in hepatic irradiation because of two significant advances in cancer treatment; three dimensional radiation therapy treatment planning and bone marrow transplantation using total body irradiation. RILD resulting from liver radiation can usually be distinguished clinically from the resulting from the preparative regime associated with bone marrow transplantation. However, both syndromes demonstrate the same pathological lesion; veno-occlusive disease. Recent evidence suggests that elevated transforming growth factor {beta} levels may play a role in the development of veno-occlusive disease. Three dimensional treatment planning offers the potential to determine the radiation dose and volume dependence of RILD, permitting the safe delivery of high doses of radiation to parts of the liver. The chief therapy for RILD is diuretics, although some advocate steroids of severe cases. The characteristics of RILD permit the development of a grading system modeled after the NCI Acute Common Toxicity Criteria, which incorporates standard criteria of hepatic dysfunction. 64 refs., 5 figs., 1 tab.

• OSTI ID: 90886
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 5 Vol. 31; ISSN 0360-3016; ISSN IOBPD3
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
56 BIOLOGY AND MEDICINE
APPLIED STUDIES
ASCITES
BIOLOGICAL PATHWAYS
BONE MARROW
DELAYED RADIATION EFFECTS
HEPATITIS
LIVER
RADIATION INJURIES
RADIATION SYNDROME
RADIOTHERAPY
TOXICITY