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Method to fabricate hollow microneedle arrays

Patent ·
OSTI ID:908048
 [1];  [2];  [3];  [2]
  1. Placitas, NM
  2. Albuquerque, NM
  3. Los Lunas, NM
+ Show Author Affiliations

An inexpensive and rapid method for fabricating arrays of hollow microneedles uses a photoetchable glass. Furthermore, the glass hollow microneedle array can be used to form a negative mold for replicating microneedles in biocompatible polymers or metals. These microneedle arrays can be used to extract fluids from plants or animals. Glucose transport through these hollow microneedles arrays has been found to be orders of magnitude more rapid than natural diffusion.

Research Organization:
Sandia National Laboratories (SNL-NM), Albuquerque, NM
Sponsoring Organization:
United States Department of Energy
DOE Contract Number:
AC04-94AL85000
Assignee:
Sandia Corporation (Albuquerque, NM)
Patent Number(s):
7,132,054
Application Number:
10/936,360
OSTI ID:
908048
Country of Publication:
United States
Language:
English

References (11)

Micromachined needles for microbiological sample and drug delivery system conference January 2003
Microneedles for transdermal drug delivery journal March 2004
Side-opened out-of-plane microneedles for microfluidic transdermal liquid transfer journal June 2003
Fabrication of true 3D microstructures in glass/ceramic materials by pulsed UV laser volumetric exposure techniques
  • Fuqua, Peter D.; Janson, Siegfried W.; Hansen, William W.
  • Optoelectronics '99 - Integrated Optoelectronic Devices, SPIE Proceedings https://doi.org/10.1117/12.352714
conference July 1999
3D microstructuring inside photosensitive glass by use of a femtosecond laser for lab-on-chip applications conference July 2003
Photoetchable glass for microsystems: tips for atomic force microscopy journal December 1993
Fabrication and simulation of novel crown-shaped microneedle array conference February 2005
Novel low cost fabrication of microneedle arrays for drug delivery applications
  • Tan, Pei Ying J.; Xu, Yuan; Chew, Yong T.
  • SPIE's International Symposium on Smart Materials, Nano-, and Micro- Smart Systems, SPIE Proceedings https://doi.org/10.1117/12.469435
conference November 2002
Fabrication technologies for microsystems utilizing photoetchable glass journal January 1996
Silicon micromachined hollow microneedles for transdermal liquid transport journal December 2003
Direct-write UV-laser microfabrication of 3D structures in lithium-aluminosilicate glass conference May 1997

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