Heightened sense for sensing: recent advances in pathogen immunoassay sensing platforms

Fischer, N; Tarasow, T; Tok, J B

doi:10.1039/b615477h

Title: Heightened sense for sensing: recent advances in pathogen immunoassay sensing platforms

Journal Article · Tue Jan 09 00:00:00 EST 2007 · The Analyst, vol. 132, no. 2, March 1, 2007, pp. 187-191

DOI:https://doi.org/10.1039/b615477h· OSTI ID:902317

Fischer, N; Tarasow, T; Tok, J B

As part of its own defense mechanism, most bacteria have developed an innate ability to enable toxic secretion to ward off potential predators or invaders. However, this naturally occurring process has been abused since over production of the bacteria's toxin molecules could render them as potential bioweapons. As these processes (also known as ''black biology'') can be clandestinely performed in a laboratory, the threat of inflicting enormous potential damage to a nation's security and economy is invariably clear and present. Thus, efficient detection of these biothreat agents in a timely and accurate manner is highly desirable. A wealth of publications describing various pathogen immuno-sensing advances has appeared over the last few years, and it is not the intent of this review article to detail each reported approach. Instead, we aim to survey a few recent highlights in hopes of providing the reader an overall sense of the breath of these sensing systems and platforms. Antigen targets are diverse and complex as they encompass proteins, whole viruses, and bacterial spores. The signaling processes for these reported immunoassays are usually based on colorimetric, optical, or electrochemical changes. Of equal interest is the type of platform in which the immunoassay can be performed. A few platforms suitable for pathogen detection are described.

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Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: W-7405-ENG-48

OSTI ID:: 902317

Report Number(s):: UCRL-JRNL-227771; TRN: US200717%%251

Journal Information:: The Analyst, vol. 132, no. 2, March 1, 2007, pp. 187-191, Vol. 132, Issue 2

Country of Publication:: United States

Language:: English

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Title: Heightened sense for sensing: recent advances in pathogen immunoassay sensing platforms

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