Transgenic knockout mice with exclusively human sickle hemoglobinand sickle cell disease
Journal Article
·
· Science
OSTI ID:900632
To create mice expressing exclusively human sicklehemoglobin (HbS), transgenic mice expressing human alpha-, gamma-, andbeta[S]-globin were generated and bred with knockout mice that haddeletions of the murine alpha- and beta-globin genes. These sickle cellmice have the major features (irreversibly sickled red cells, anemia,multiorgan pathology) found in humans with sickle cell disease and, assuch, represent a useful in vivo system to accelerate the development ofimproved therapies for this common genetic disease.
- Research Organization:
- Ernest Orlando Lawrence Berkeley NationalLaboratory, Berkeley, CA (US)
- Sponsoring Organization:
- USOER; National Heart Lung and Blood Institute (NHLBI)grants HL31579 and HL20985 to the Northern California ComprehensiveSickle Cell Cente r, A Red Cell Program Project Grant (DK32094) and fromthe National Inst. of Diabetes, Digestive and Kidney Diseases, a NHLBIcontract to the Sickle Cell Disease Centralized Pathology Unit and an NIHShared Instrume
- DOE Contract Number:
- AC02-05CH11231
- OSTI ID:
- 900632
- Report Number(s):
- LBNL--40891
- Journal Information:
- Science, Journal Name: Science Journal Issue: 5339 Vol. 278; ISSN 0193-4511; ISSN SCEHDK
- Country of Publication:
- United States
- Language:
- English
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