Particle Interactions in DNA-laden Flows

Technical Report · Tue Dec 20 00:00:00 EST 2005

DOI:https://doi.org/10.2172/898439· OSTI ID:898439

Bybee, M D; Miller, G H; Trebotich, D

Microfluidic devices are becoming state-of-the-art in many significant applications including pathogen detection, continuous monitoring, and drug delivery. Numerical algorithms which can simulate flows of complex fluids within these devices are needed for their development and optimization. A method is being developed at LLNL by Trebotich et. al. [30] for simulations of DNA-laden flows in complex microscale geometries such as packed bed reactors and pillar chips. In this method an incompressible Newtonian fluid is discretized with Cartesian grid embedded boundary methods, and the DNA is represented by a bead-rod polymer model. The fluid and polymer are coupled through a body force. In its current state, polymer-surface interactions are treated as elastic collisions between beads and surface, and polymer-polymer interactions are neglected. Implementation of polymer-polymer interactions is the main objective of this work. It is achieved by two methods: (1) a rigid constraint whereby rods elastically bounce off one another, and (2) a smooth potential acting between rods. In addition, a smooth potential is also implemented for the polymer-surface interactions. Background information will also be presented as well as related work by other researchers.

• Research Organization: Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: W-7405-ENG-48
• OSTI ID: 898439
• Report Number(s): UCRL-TR-217843; TRN: US0701909
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS
99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE
ALGORITHMS
DETECTION
DNA
IMPLEMENTATION
LAWRENCE LIVERMORE NATIONAL LABORATORY
MONITORING
OPTIMIZATION
PACKED BEDS
PARTICLE INTERACTIONS
PATHOGENS
POLYMERS