Synthesis of 4-(3'-[125I]iodoanilino)-6,7-dialkoxyquinazolines:radiolabeled epidermal growth factor receptor tyrosine kinaseinhibitors
Journal Article
·
· Journal of Labelled Compounds andRadiopharmaceuticals
OSTI ID:894401
The preparation of two radioiodinated analogs of theepidermal growth factor receptor tyrosine kinase (EGFrTK) inhibitorPD153035(4-(3'-bromoanilino)-6,7-dimethoxyquinazoline) are reportedherein. The two analogs,4-(3'-[125I]iodoanilino)-6,7-dimethoxyquinazoline and4-(3'-[125I]iodoanilino)-6,7-diethoxyquinazoline, were synthesizedviaiododestannylation of the corresponding4-(3'-trimethylstannylanilino)-6,7-dialkoxyquinazolines to form thedesired I-125 labeled products in good yield and high radiochemicalpurity (>99 percent).
- Research Organization:
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Sponsoring Organization:
- USDOE; US Department of Defense DAMD17-98-1-8064
- DOE Contract Number:
- DE-AC02-05CH11231; OTHER:US DOD:DAMD17-98-1-8064
- OSTI ID:
- 894401
- Report Number(s):
- LBNL-44443; m; R&D Project: 802F01
- Journal Information:
- Journal of Labelled Compounds andRadiopharmaceuticals, Vol. 43, Issue 12; Related Information: Journal Publication Date: 10/30/2000
- Country of Publication:
- United States
- Language:
- English
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