Nanoparticle Labels/ Electrochemical Immunosensor for Detection of Biomarkers
Conference
·
OSTI ID:888704
A sensitive electrochemical immunosensor based on poly(guanine) functionalized silica nanoparticle label has been developed for the detection of protein biomarker, biomarker recombinant human tumor necrosis factor-a(TNF-a).This method is simple, selective, and reproducible for trace biomarker analysis. A remarkable LOD has been achieved through dual signal amplification by poly[G] functionalized silica NPs and catalytic guanine oxidation. The work demonstrates the feasibility of developing an inexpensive, sensitive, and portable device for multiplexed diagnoses of different protein biomarkers.
- Research Organization:
- Pacific Northwest National Laboratory (PNNL), Richland, WA (US)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC05-76RL01830
- OSTI ID:
- 888704
- Report Number(s):
- PNNL-SA-49687
- Country of Publication:
- United States
- Language:
- English
Similar Records
Sensitive Immunoassay of a Biomarker Tumor Necrosis Factor-[alpha] Based on Poly(guanine)-Functionalized Silica Nanoparticle Label
Electroactive Silica Nanoparticles for Biological Labeling
Immunosensors Based on Functional Nanoparticle Labels
Journal Article
·
Sun Oct 01 00:00:00 EDT 2006
· Analytical Chemistry, 78(19):6974-6979
·
OSTI ID:893245
Electroactive Silica Nanoparticles for Biological Labeling
Journal Article
·
Tue Aug 29 00:00:00 EDT 2006
· Small, 2(10):1134-1138
·
OSTI ID:891425
Immunosensors Based on Functional Nanoparticle Labels
Conference
·
Fri Nov 30 23:00:00 EST 2007
·
OSTI ID:947064