Relation between mRNA expression and sequence information in Desulfovibrio vulgaris: Combinatorial contributions of upstream regulatory motifs and coding sequence features to variations in mRNA abundance

Journal Article · Fri May 26 04:00:00 EDT 2006 · Biochemical and Biophysical Research Communications, 344(1):114-121

DOI:https://doi.org/10.1016/j.bbrc.2006.03.124· OSTI ID:885444

Wu, Gang; Nie, Lei; Zhang, Weiwen

ABSTRACT-The context-dependent expression of genes is the core for biological activities, and significant attention has been given to identification of various factors contributing to gene expression at genomic scale. However, so far this type of analysis has been focused whether on relation between mRNA expression and non-coding sequence features such as upstream regulatory motifs or on correlation between mRN abundance and non-random features in coding sequences (e.g. codon usage and amino acid usage). In this study multiple regression analyses of the mRNA abundance and all sequence information in Desulfovibrio vulgaris were performed, with the goal to investigate how much coding and non-coding sequence features contribute to the variations in mRNA expression, and in what manner they act together...

• Research Organization: Pacific Northwest National Laboratory (PNNL), Richland, WA (US)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC05-76RL01830
• OSTI ID: 885444
• Report Number(s): PNNL-SA-46106
• Journal Information: Biochemical and Biophysical Research Communications, 344(1):114-121, Journal Name: Biochemical and Biophysical Research Communications, 344(1):114-121 Journal Issue: 1 Vol. 344; ISSN 0006-291X; ISSN BBRCA9
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ABUNDANCE
AMINO ACIDS
CODONS
DESULFOVIBRIO
GENES
mRNA expression and sequence information on D. vulgaris