A New Class of Silica Crosslinked Micellar Core-Shell /nanoparticles."
Journal Article
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· Journal of the American Chemical Society, 128(19):6447-6453
Micellar nanoparticles made of surfactants and polymers have attracted wide attention in the materials and biomedical community for controlled drug delivery, molecular imaging and sensing; however, their long-term stability remains a topic of intense study. Here we report a new class of robust, ultrafine (10nm) silica core-shell nanoparticles formed from silica crosslinked, individual block copolymer micelles. Compared with pure polymer micelles, the new core-shell nanoparticles have significantly improved stability and do not break down during dilution. They also achieve much higher loading capacity for a wide range of chemicals, with the entrapped molecules slowly released over a much longer period of time. A wide range of functional groups can be easily incorporated through co-condensation with the silica matrix. The potential to deliver hydrophobic agents into cancer cells has been demonstrated. Because of their unique properties, these novel core-shell nanoparticles could potentially provide a new nanomedicine platform for imaging, detection and treatment.
- Research Organization:
- Pacific Northwest National Laboratory (PNNL), Richland, WA (US)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC05-76RL01830
- OSTI ID:
- 884823
- Report Number(s):
- PNNL-SA-48389
- Journal Information:
- Journal of the American Chemical Society, 128(19):6447-6453, Journal Name: Journal of the American Chemical Society, 128(19):6447-6453 Journal Issue: 19 Vol. 128; ISSN JACSAT; ISSN 0002-7863
- Country of Publication:
- United States
- Language:
- English