High-resolution NMR spectroscopy of biological tissues usingprojected Magic Angle Spinning

Journal Article · Thu Jan 27 04:00:00 EST 2005 · Magnetic Resonance in Medicine

DOI:https://doi.org/10.1002/mrm.20585· OSTI ID:882742

Martin, Rachel W; Jachmann, Rebecca C; Sakellariou, Dimitris; Nielsen, Ulla Gro; Pines, Alexander

High-resolution NMR spectra of materials subject toanisotropic broadening are usually obtained by rotating the sample aboutthe magic angle, which is 54.7 degrees to the static magnetic field. Inprojected Magic Angle Spinning (p-MAS), the sample is spun about twoangles, neither of which is the magic angle. This provides a method ofobtaining isotropic spectra while spinning at shallow angles. The p-MASexperiment may be used in situations where spinning the sample at themagic angle is not possible due to geometric or other constraints,allowing the choice of spinning angle to be determined by factors such asthe shape of the sample, rather than by the spin physics. The applicationof this technique to bovine tissue samples is demonstrated as a proof ofprinciple for future biological or medical applications.

• Research Organization: Ernest Orlando Lawrence Berkeley NationalLaboratory, Berkeley, CA (US)
• Sponsoring Organization: USDOE Director. Office of Science. Office of Basic EnergySciences. Materials Science and Engineering Division; Department of theArmy Contract DAMD 17-03-1-0476; Carlsbergfondet ANS-0634/20
• DOE Contract Number: AC02-05CH11231
• OSTI ID: 882742
• Report Number(s): LBNL--55207; BnR: KC0203010
• Journal Information: Magnetic Resonance in Medicine, Journal Name: Magnetic Resonance in Medicine Vol. 54
• Country of Publication: United States
• Language: English

Related Subjects

36 MATERIALS SCIENCE
Nuclear Magnetic Resonance NMR magnetic susceptibilitybroadening rotating solids biological tissue