Sample Desorption/Onization From Mesoporous Silica

Iyer, Srinivas; Dattelbaum, Andrew M

Sample Desorption/Onization From Mesoporous Silica

Patent · Tue Oct 25 04:00:00 EDT 2005

OSTI ID:880504

Iyer, Srinivas ^[1]; Dattelbaum, Andrew M ^[1]

Los Alamos, NM

Mesoporous silica is shown to be a sample holder for laser desorption/ionization of mass spectrometry. Supported mesoporous silica was prepared by coating an ethanolic silicate solution having a removable surfactant onto a substrate to produce a self-assembled, ordered, nanocomposite silica thin film. The surfactant was chosen to provide a desired pore size between about 1 nanometer diameter and 50 nanometers diameter. Removal of the surfactant resulted in a mesoporous silica thin film on the substrate. Samples having a molecular weight below 1000, such as C.sub.60 and tryptophan, were adsorbed onto and into the mesoporous silica thin film sample holder and analyzed using laser desorption/ionization mass spectrometry.

Research Organization:: Los Alamos National Laboratory

DOE Contract Number:: W-7405-ENG-36

Assignee:: The Regents of the University of California (Los Alamos, NM)

Patent Number(s):: US 6958480

Application Number:: 10/877690

OSTI ID:: 880504

Country of Publication:: United States

Language:: English

References (12)

Novel method for matrix-assisted laser mass spectrometry of proteins Zhao, Shankai.; Somayajula, Kasi V.; Sharkey, Andrew G. Analytical Chemistry, Vol. 63, Issue 5 https://doi.org/10.1021/ac00005a012	journal	March 1991
Desorption–ionization mass spectrometry on porous silicon Wei, Jing; Buriak, Jillian M.; Siuzdak, Gary Nature, Vol. 399, Issue 6733 https://doi.org/10.1038/20400	journal	May 1999
Desorption/ionization on silicon (DIOS) mass spectrometry: background and applications Lewis, Warren G.; Shen, Zhouxin; Finn, M. G. International Journal of Mass Spectrometry, Vol. 226, Issue 1 https://doi.org/10.1016/S1387-3806(02)00973-9	journal	March 2003
Laser desorption-mass spectrometry of polar nonvolatile bio-organic molecules Posthumus, M. A.; Kistemaker, P. G.; Meuzelaar, H. L. C. Analytical Chemistry, Vol. 50, Issue 7 https://doi.org/10.1021/ac50029a040	journal	June 1978
Californium-252 plasma desorption mass spectroscopy Macfarlane, R.; Torgerson, D. Science, Vol. 191, Issue 4230 https://doi.org/10.1126/science.1251202	journal	March 1976
Detection of biomolecules on surfaces using ion-beam-induced desorption and multiphoton resonance ionization Hrubowchak, D. M.; Ervin, M. H.; Wood, M. C. Analytical Chemistry, Vol. 63, Issue 18 https://doi.org/10.1021/ac00018a010	journal	September 1991
Laser desorption substrate effects Zhan, Q.; Wright, S.; Zenobi, R. Journal of the American Society for Mass Spectrometry, Vol. 8, Issue 5 https://doi.org/10.1016/S1044-0305(97)00005-6	journal	May 1997
Some new field desorption techniques Beckey, H. D.; Heindrichs, A.; Winkler, H. U. International Journal of Mass Spectrometry and Ion Physics, Vol. 3, Issue 6 https://doi.org/10.1016/0020-7381(70)80009-2	journal	March 1970
Desorption−Ionization Mass Spectrometry Using Deposited Nanostructured Silicon Films Cuiffi, Joseph D.; Hayes, Daniel J.; Fonash, Stephen J. Analytical Chemistry, Vol. 73, Issue 6 https://doi.org/10.1021/ac001081k	journal	March 2001
Scalable Synthesis of a New Class of Polymer Microrods by a Liquid-Liquid Dispersion Technique Alargova, R. G.; Bhatt, K. H.; Paunov, V. N. Advanced Materials, Vol. 16, Issue 18 https://doi.org/10.1002/adma.200400112	journal	September 2004
Studies of silicon-nitride (Si3N4) using laser ablation mass spectrometry Wang, S. L.; Ledingham, K. W. D.; Jia, W. J. Applied Surface Science, Vol. 93, Issue 3 https://doi.org/10.1016/0169-4332(95)00370-3	journal	March 1996
Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons Karas, Michael.; Hillenkamp, Franz. Analytical Chemistry, Vol. 60, Issue 20 https://doi.org/10.1021/ac00171a028	journal	October 1988

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