Method And Apparatus For High Resolution Ex-Situ Nmr Spectroscopy

Patent · Tue Jan 06 00:00:00 EST 2004

OSTI ID:879818

Pines, Alexander ^[1]; Meriles, Carlos A ^[2]; Heise, Henrike ^[3]; Sakellariou, Dimitrios ^[4]; Moule, Adam ^[1]

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1. Berkeley, CA
2. El Cerrito, CA
3. Goettingen, DE
4. Oakland, CA

A method and apparatus for ex-situ nuclear magnetic resonance spectroscopy for use on samples outside the physical limits of the magnets in inhomogeneous static and radio-frequency fields. Chemical shift spectra can be resolved with the method using sequences of correlated, composite z-rotation pulses in the presence of spatially matched static and radio frequency field gradients producing nutation echoes. The amplitude of the echoes is modulated by the chemical shift interaction and an inhomogeneity free FID may be recovered by stroboscopically sampling the maxima of the echoes. In an alternative embodiment, full-passage adiabatic pulses are consecutively applied. One embodiment of the apparatus generates a static magnetic field that has a variable saddle point.

• Research Organization: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
• DOE Contract Number: AC03-76SF00098
• Assignee: The Regents of the University of California (Oakland, CA)
• Patent Number(s): US 6,674,282
• Application Number: 10/218974
• OSTI ID: 879818
• Country of Publication: United States
• Language: English