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Antimicrobial Polymer

Patent ·
OSTI ID:879709
 [1];  [2];  [3]
  1. Utica, OH
  2. Flint, MI
  3. Ann Arbor, MI
+ Show Author Affiliations

A polymeric composition having antimicrobial properties and a process for rendering the surface of a substrate antimicrobial are disclosed. The polymeric composition comprises a crosslinked chemical combination of (i) a polymer having amino group-containing side chains along a backbone forming the polymer, (ii) an antimicrobial agent selected from metals, metal alloys, metal salts, metal complexes and mixtures thereof, and (iii) a crosslinking agent containing functional groups capable of reacting with the amino groups. In one example embodiment, the polymer is a polyamide formed from a maleic anhydride or maleic acid ester monomer and alkylamines thereby producing a polyamide having amino substituted alkyl chains on one side of the polyamide backbone; the crosslinking agent is a phosphine having the general formula (A).sub.3 P wherein A is hydroxyalkyl; and the metallic antimicrobial agent is selected from chelated silver ions, silver metal, chelated copper ions, copper metal, chelated zinc ions, zinc metal and mixtures thereof.

Research Organization:
MIDWEST RESEARCH INSTITUTE
Assignee:
Michigan Biotechnology Institute (Lansing, MI)
Patent Number(s):
US 6,797,743
Application Number:
09/850324
OSTI ID:
879709
Country of Publication:
United States
Language:
English

References (17)

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P(CH2OH)3? a new coupling reagent for the covalent immobilisation of enzymes journal January 1994
Water-soluble tris(hydroxymethyl)phosphine complexes with nickel, palladium, and platinum. Crystal structure of [Pd{P(CH2OH)3}4].cntdot.CH3 journal July 1992
Binding of the basement-membrane glycoprotein laminin to glycosaminoglycans. An affinity-chromatography study journal December 1981
Polyacrylhydrazido-agarose: Preparation via periodate oxidation and use for enzyme immobilization and affinity chromatography journal October 1981
Immobilization of Saccharides and Peptides on 96-Well Microtiter Plates Coated with Methyl Vinyl Ether–Maleic Anhydride Copolymer journal June 1998
Polyacrylic polyhydrazides as reagents for detection of glycoproteins journal August 1989
Immobilization of protein ligands with methyl vinyl ether-maleic anhydride copolymer journal April 1992
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Immobilised phosphines incorporating the chiral biopolymers chitosan and chitin journal January 1994
Oriented immobilization of periodateoxidized monoclonal antibodies on amino and hydrazide derivatives of eupergit C journal February 1990
The derivatization of oxidized polysaccharides for protein immobilization and affinity chromotography journal March 1976
Immobilization of glycoconjugates by their oligosaccharides: Use of hydrazido-derivatized matrices journal November 1990

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