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Method And Apparatus For Reducing Sample Dispersion In Turns And Junctions Of Micro-Channel Systems

Patent ·
OSTI ID:879675

What is disclosed pertains to improvement in the performance of microchannel devices by providing turns, wyes, tees, and other junctions that produce little dispersion of a sample as it traverses the turn or junction. The reduced dispersion results from contraction and expansion regions that reduce the cross-sectional area over some portion of the turn or junction. By carefully designing the geometries of these regions, sample dispersion in turns and junctions is reduced to levels comparable to the effects of ordinary diffusion. The low dispersion features are particularly suited for microfluidic devices and systems using either electromotive force, pressure, or combinations thereof as the principle of fluid transport. Such microfluidic devices and systems are useful for separation of components, sample transport, reaction, mixing, dilution or synthesis, or combinations thereof.

Research Organization:
Sandia Corporation
DOE Contract Number:
AC04-94AL85000
Assignee:
Sandia Corporation (Albuquerque, NM)
Patent Number(s):
US 6733730
Application Number:
09/707337
OSTI ID:
879675
Country of Publication:
United States
Language:
English

References (7)

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Wormhole growth in soluble porous materials journal September 1990
Dispersion Sources for Compact Geometries on Microchips journal September 1998
Free boundary problem of ECM by alternating-field technique on inverted plane journal November 1975
Effects of Injection Schemes and Column Geometry on the Performance of Microchip Electrophoresis Devices journal April 1994
Coiled columns and resolution in gas chromatography journal January 1960
Contribution of capillary coiling to zone dispersion in capillary zone electrophoresis journal January 1995

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