SYNTHESIS OF PROTEINS BY NATIVE CHEMICAL LIGATION USING FMOC-BASED CHEMISTRY
Journal Article
·
· Protein and Peptide Letters
C-terminal peptide {alpha}-thioesters are valuable intermediates in the synthesis/semisynthesis of proteins by native chemical ligation. They are prepared either by solid-phase peptide synthesis (SPPS) or biosynthetically by protein splicing techniques. The present paper reviews the different methods available for the chemical synthesis of peptide {alpha}-thioesters using Fmoc-based SPPS.
- Research Organization:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- W-7405-ENG-48
- OSTI ID:
- 875926
- Report Number(s):
- UCRL-JRNL-209192
- Journal Information:
- Protein and Peptide Letters, Journal Name: Protein and Peptide Letters Journal Issue: 8 Vol. 12
- Country of Publication:
- United States
- Language:
- English
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