Treatment of addiction and addiction-related behavior
- Manorville, NY
- Cos Cob, CT
The present invention provides a highly efficient method for treating substance addiction and for changing addiction-related behavior of a mammal suffering from substance addiction. The method includes administering to a mammal an effective amount of gamma vinylGABA or a pharmaceutically acceptable salt thereof. The present invention also provides a method of treatment of cocaine, morphine, heroin, nicotine, amphetamine, methamphetamine, or ethanol addiction by treating a mammal with an effective amount of gamma vinylGABA or a pharmaceutically acceptable salt thereof. In one embodiment, the method of the present invention includes administering to the mammal an effective amount of a composition which increases central nervous system GABA levels wherein the effective amount is sufficient to diminish, inhibit or eliminate behavior associated with craving or use of drugs of abuse. The composition includes GVG, gabapentin, valproic acid, progabide, gamma-hydroxybutyric acid, fengabine, cetylGABA, topiramate or tiagabine or a pharmaceutically acceptable salt thereof, or an enantiomer or a racemic mixture thereof.
- Research Organization:
- Brookhaven National Laboratory (BNL), Upton, NY (United States)
- DOE Contract Number:
- AC02-98CH10886
- Assignee:
- Brookhaven Science Associates (Upton, NY)
- Patent Number(s):
- US 6541520
- OSTI ID:
- 875138
- Country of Publication:
- United States
- Language:
- English
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addiction
addiction-related
behavior
provides
highly
efficient
method
treating
substance
changing
mammal
suffering
administering
effective
amount
gamma
vinylgaba
pharmaceutically
acceptable
salt
cocaine
morphine
heroin
nicotine
amphetamine
methamphetamine
ethanol
embodiment
composition
increases
central
nervous
gaba
levels
sufficient
diminish
inhibit
eliminate
associated
craving
drugs
abuse
gvg
gabapentin
valproic
acid
progabide
gamma-hydroxybutyric
fengabine
cetylgaba
topiramate
tiagabine
enantiomer
racemic
mixture
pharmaceutically acceptable
efficient method
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