Treatment of addiction and addiction-related behavior

Dewey, Stephen L; Brodie, Jonathan D

Treatment of addiction and addiction-related behavior

Patent · Tue Dec 31 23:00:00 EST 2002

OSTI ID:875138

Dewey, Stephen L ^[1]; Brodie, Jonathan D ^[2]

Manorville, NY
Cos Cob, CT

The present invention provides a highly efficient method for treating substance addiction and for changing addiction-related behavior of a mammal suffering from substance addiction. The method includes administering to a mammal an effective amount of gamma vinylGABA or a pharmaceutically acceptable salt thereof. The present invention also provides a method of treatment of cocaine, morphine, heroin, nicotine, amphetamine, methamphetamine, or ethanol addiction by treating a mammal with an effective amount of gamma vinylGABA or a pharmaceutically acceptable salt thereof. In one embodiment, the method of the present invention includes administering to the mammal an effective amount of a composition which increases central nervous system GABA levels wherein the effective amount is sufficient to diminish, inhibit or eliminate behavior associated with craving or use of drugs of abuse. The composition includes GVG, gabapentin, valproic acid, progabide, gamma-hydroxybutyric acid, fengabine, cetylGABA, topiramate or tiagabine or a pharmaceutically acceptable salt thereof, or an enantiomer or a racemic mixture thereof.

View Patent

Research Organization:: Brookhaven National Laboratory (BNL), Upton, NY

DOE Contract Number:: AC02-98CH10886

Assignee:: Brookhaven Science Associates (Upton, NY)

Patent Number(s):: US 6541520

OSTI ID:: 875138

Country of Publication:: United States

Language:: English

References (37)

Imaging endogenous dopamine competition with [11C]raclopride in the human brain Volkow, Nora D.; Wang, Gene-Jack; Fowler, Joanna S. Synapse, Vol. 16, Issue 4 https://doi.org/10.1002/syn.890160402	journal	April 1994
Vigabatrin: A Review of its Pharmacodynamic and Pharmacokinetic Properties, and Therapeutic Potential in Epilepsy and Disorders of Motor Control Grant, Susan M.; Heel, Rennie C. Drugs, Vol. 41, Issue 6 https://doi.org/10.2165/00003495-199141060-00007	journal	January 1991
Effects of central cholinergic blockade on striatal dopamine release measured with positron emission tomography in normal human subjects. Dewey, S. L.; Smith, G. S.; Logan, J. Proceedings of the National Academy of Sciences, Vol. 90, Issue 24 https://doi.org/10.1073/pnas.90.24.11816	journal	December 1993
Gamma-vinyl GABA attenuates cocaine-induced lowering of brain stimulation reward thresholds Kushner, Stephanie A.; Dewey, Stephen L.; Kornetsky, C. Psychopharmacology, Vol. 133, Issue 4 https://doi.org/10.1007/s002130050418	journal	October 1997
Systemic nicotine-induced dopamine release in the rat nucleus accumbens is regulated by nicotinic receptors in the ventral tegmental area Nisell, Magnus; Nomikos, George G.; Svensson, Torgny H. Synapse, Vol. 16, Issue 1 https://doi.org/10.1002/syn.890160105	journal	January 1994
Conditioned place preference induced by Δ9-tetrahydrocannabinol: comparison with cocaine, morphine, and food reward Lepore, Marino; Vorel, Stanislav R.; Lowinson, Joyce Life Sciences, Vol. 56, Issue 23-24 https://doi.org/10.1016/0024-3205(95)00191-8	journal	May 1995
On the potassium conductance increase activated by GABAB and dopamine D2 receptors in rat substantia nigra neurones. Lacey, M. G.; Mercuri, N. B.; North, R. A. The Journal of Physiology, Vol. 401, Issue 1 https://doi.org/10.1113/jphysiol.1988.sp017171	journal	July 1988
Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Di Chiara, G.; Imperato, A. Proceedings of the National Academy of Sciences, Vol. 85, Issue 14 https://doi.org/10.1073/pnas.85.14.5274	journal	July 1988
Activation of ventral tegmental GABAB receptors inhibits morphine-induced place preference in rats Tsuji, Minoru; Nakagawa, Yutaka; Ishibashi, Yoshinori European Journal of Pharmacology, Vol. 313, Issue 3 https://doi.org/10.1016/0014-2999(96)00642-5	journal	October 1996
Baclofen suppression of cocaine self-administration: demonstration using a discrete trials procedure Roberts, D. C. S.; Andrews, Monique M. Psychopharmacology, Vol. 131, Issue 3 https://doi.org/10.1007/s002130050293	journal	June 1997
Place Conditioning: A Simple and Effective Method for Assessing the Motivational Properties of Drugs van der Kooy, Derek Methods of Assessing the Reinforcing Properties of Abused Drugs https://doi.org/10.1007/978-1-4612-4812-5_13	book	January 1987
Nicotine Dependence, Midbrain Dopamine Systems and Psychiatric Disorders Nisell, Magnus; Nomikos, George G.; Svensson, Torgny H. Pharmacology & Toxicology, Vol. 76, Issue 3 https://doi.org/10.1111/j.1600-0773.1995.tb00123.x	journal	March 1995
Graphical Analysis of Reversible Radioligand Binding from Time—Activity Measurements Applied to [ N - ¹¹ C-Methyl]-(−)-Cocaine PET Studies in Human Subjects Logan, Jean; Fowler, Joanna S.; Volkow, Nora D. Journal of Cerebral Blood Flow & Metabolism, Vol. 10, Issue 5 https://doi.org/10.1038/jcbfm.1990.127	journal	September 1990
Apparent absence of nicotine-induced conditioned place preference in rats Clarke, P. B. S.; Fibiger, H. C. Psychopharmacology, Vol. 92, Issue 1 https://doi.org/10.1007/BF00215484	journal	May 1987
Treatment of Cocaine Abuse: Pharmacotherapy Kleber, Herbert D. Ciba Foundation Symposium 166 ‐ Cocaine: Scientific and Social Dimensions: Cocaine: Scientific and Social Dimensions: Ciba Foundation Symposium 166 https://doi.org/10.1002/9780470514245.ch11	book	September 2007
Pharmacological treatment of tobacco dependence Jarvik, Murray E.; Henningfield, Jack E. Pharmacology Biochemistry and Behavior, Vol. 30, Issue 1 https://doi.org/10.1016/0091-3057(88)90456-X	journal	May 1988
GABAergic inhibition of endogenous dopamine release measured in vivo with 11C-raclopride and positron emission tomography Dewey, Sl; Smith, Gs; Logan, J. The Journal of Neuroscience, Vol. 12, Issue 10 https://doi.org/10.1523/JNEUROSCI.12-10-03773.1992	journal	October 1992
GABAergic attenuation of cocaine-induced dopamine release and locomotor activity Dewey, Stephen L.; Chaurasia, Chandra S.; Chen, Chu-En Synapse, Vol. 25, Issue 4 https://doi.org/10.1002/(SICI)1098-2396(199704)25:4<393::AID-SYN11>3.0.CO;2-W	journal	April 1997
Acute administration of nicotine increases the in vivo extracellular levels of dopamine, 3,4-dihydroxyphenylacetic acid and ascorbic acid preferentially in the nucleus accumbens of the rat: Comparison with caudate-putamen Brazell, M.; Mitchell, S.; Joseph, M. Neuropharmacology, Vol. 29, Issue 12 https://doi.org/10.1016/0028-3908(90)90042-P	journal	December 1990
Presynaptic Nicotinic Modulation of Dopamine Release in the Three Ascending Pathways Studied by In Vivo Microdialysis: Comparison of Naive and Chronic Nicotine-Treated Rats Marshall, David L.; Redfern, Peter H.; Wonnacott, Susan Journal of Neurochemistry, Vol. 68, Issue 4 https://doi.org/10.1046/j.1471-4159.1997.68041511.x	journal	April 1997
Infusion of Nicotine in the Ventral Tegmental Area or the Nucleus Accumbens of the Rat Differentially Affects Accumbal Dopamine Release Nisell, Magnus; Nomikos, George G.; Svensson, Torgny H. Pharmacology & Toxicology, Vol. 75, Issue 6 https://doi.org/10.1111/j.1600-0773.1994.tb00373.x	journal	December 1994
A Comparison of Sustained-Release Bupropion and Placebo for Smoking Cessation Hurt, Richard D.; Sachs, David P. L.; Glover, Elbert D. New England Journal of Medicine, Vol. 337, Issue 17 https://doi.org/10.1056/NEJM199710233371703	journal	October 1997
Cigarette smokers self-administer intravenous nicotine Henningfield, Jack E.; Miyasato, Katsumasa; Jasinski, Donald R. Pharmacology Biochemistry and Behavior, Vol. 19, Issue 5 https://doi.org/10.1016/0091-3057(83)90099-0	journal	November 1983
Baclofen Attenuates the Reinforcing Effects of Cocaine in Rats Roberts, D. Neuropsychopharmacology, Vol. 15, Issue 4 https://doi.org/10.1016/0893-133X(96)00002-4	journal	October 1996
Control of behavior by intravenous nicotine injections in human subjects Henningfield, Jack E.; Goldberg, Steven R. Pharmacology Biochemistry and Behavior, Vol. 19, Issue 6 https://doi.org/10.1016/0091-3057(83)90409-4	journal	December 1983
?-VINYL GABA (4-amino-hex-5-enoic acid), A NEW SELECTIVE IRREVERSIBLE INHIBITOR OF GABA-T: EFFECTS ON BRAIN GABA METABOLISM IN MICE Jung, M. J.; Lippert, B.; Metcalf, B. W. Journal of Neurochemistry, Vol. 29, Issue 5 https://doi.org/10.1111/j.1471-4159.1977.tb10721.x	journal	November 1977
Self-administration in rats allowed unlimited access to nicotine Valentine, James D.; Hokanson, Jonathan S.; Matta, Shannon G. Psychopharmacology, Vol. 133, Issue 3 https://doi.org/10.1007/s002130050405	journal	October 1997
Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs Pontieri, Francesco E.; Tanda, Gianluigi; Orzi, Francesco Nature, Vol. 382, Issue 6588 https://doi.org/10.1038/382255a0	journal	July 1996
Amphetamine and vigabatrin down regulate aromatic l-amino acid decarboxylase mRNA levels Buckland, Paul R.; Spurlock, Gillian; McGuffin, Peter Molecular Brain Research, Vol. 35, Issue 1-2 https://doi.org/10.1016/0169-328X(95)00182-R	journal	January 1996
Lack of tolerance to nicotine-induced dopamine release in the nucleus accumbens Damsma, Geert; Day, Jamie; Fibiger, Hans C. European Journal of Pharmacology, Vol. 168, Issue 3 https://doi.org/10.1016/0014-2999(89)90798-X	journal	September 1989
A novel strategy for the treatment of cocaine addiction Dewey, Stephen L.; Morgan, Alexander E.; Ashby, Charles R. Synapse, Vol. 30, Issue 2 https://doi.org/10.1002/(SICI)1098-2396(199810)30:2<119::AID-SYN1>3.0.CO;2-F	journal	October 1998
Presynaptic regulation of neurotransmitter release in the brain: Facts and hypothesis Chesselet, M. -F. Neuroscience, Vol. 12, Issue 2 https://doi.org/10.1016/0306-4522(84)90058-7	journal	June 1984
Cocaine reward models: Conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice Sora, I.; Wichems, C.; Takahashi, N. Proceedings of the National Academy of Sciences, Vol. 95, Issue 13 https://doi.org/10.1073/pnas.95.13.7699	journal	June 1998
Pharmacologic characterization of nicotine-induced conditioned place preference Fudala, Paul J.; Teoh, K. W.; Iwamoto, Edgar T. Pharmacology Biochemistry and Behavior, Vol. 22, Issue 2 https://doi.org/10.1016/0091-3057(85)90384-3	journal	February 1985
Basic aspects of GABA-transmission in alcoholism, with particular reference to GABA-transaminase Sherif, Fathi M.; Tawati, Ahmed M.; Ahmed, Saleem S. European Neuropsychopharmacology, Vol. 7, Issue 1 https://doi.org/10.1016/S0924-977X(96)00383-5	journal	February 1997
Nicotine preferentially stimulates dopamine release in the limbic system of freely moving rats Imperato, Assunta; Mulas, Angelina; Di Chiara, Gaetano European Journal of Pharmacology, Vol. 132, Issue 2-3 https://doi.org/10.1016/0014-2999(86)90629-1	journal	December 1986
Striatal binding of the PET ligand11C-raclopride is altered by drugs that modify synaptic dopamine levels Dewey, Stephen L.; Smith, Gwenn S.; Logan, Jean Synapse, Vol. 13, Issue 4 https://doi.org/10.1002/syn.890130407	journal	April 1993

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