Optically generated ultrasound for enhanced drug delivery

Patent · Tue Jan 01 00:00:00 EST 2002

OSTI ID:874886

Visuri, Steven R ^[1]; Campbell, Heather L ^[2]; Da Silva, Luiz ^[3]

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1. Livermore, CA
2. Baltimore, MD
3. Danville, CA

High frequency acoustic waves, analogous to ultrasound, can enhance the delivery of therapeutic compounds into cells. The compounds delivered may be chemotherapeutic drugs, antibiotics, photodynamic drugs or gene therapies. The therapeutic compounds are administered systemically, or preferably locally to the targeted site. Local delivery can be accomplished through a needle, cannula, or through a variety of vascular catheters, depending on the location of routes of access. To enhance the systemic or local delivery of the therapeutic compounds, high frequency acoustic waves are generated locally near the target site, and preferably near the site of compound administration. The acoustic waves are produced via laser radiation interaction with an absorbing media and can be produced via thermoelastic expansion, thermodynamic vaporization, material ablation, or plasma formation. Acoustic waves have the effect of temporarily permeabilizing the membranes of local cells, increasing the diffusion of the therapeutic compound into the cells, allowing for decreased total body dosages, decreased side effects, and enabling new therapies.

• Research Organization: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
• DOE Contract Number: W-7405-ENG-48
• Assignee: The Regents of the University of California (Oakland, CA)
• Patent Number(s): US 6484052
• OSTI ID: 874886
• Country of Publication: United States
• Language: English

Related Subjects

optically
generated
ultrasound
enhanced
drug
delivery
frequency
acoustic
waves
analogous
enhance
therapeutic
compounds
cells
delivered
chemotherapeutic
drugs
antibiotics
photodynamic
therapies
administered
systemically
locally
targeted
site
local
accomplished
needle
cannula
variety
vascular
catheters
depending
location
routes
access
systemic
near
target
compound
administration
produced
via
laser
radiation
interaction
absorbing
media
thermoelastic
expansion
thermodynamic
vaporization
material
ablation
plasma
formation
effect
temporarily
permeabilizing
membranes
increasing
diffusion
allowing
decreased
total
dosages
effects
enabling
laser radiation
acoustic wave
drug delivery
frequency acoustic
/604/606/