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Micro-machined calorimetric biosensors

Patent ·
OSTI ID:874661
 [1];  [2];  [3];  [1];  [4];  [1];  [1]
  1. Knoxville, TN
  2. Loudon, TN
  3. Plano, TX
  4. Powell, TN
+ Show Author Affiliations

A method and apparatus are provided for detecting and monitoring micro-volumetric enthalpic changes caused by molecular reactions. Micro-machining techniques are used to create very small thermally isolated masses incorporating temperature-sensitive circuitry. The thermally isolated masses are provided with a molecular layer or coating, and the temperature-sensitive circuitry provides an indication when the molecules of the coating are involved in an enthalpic reaction. The thermally isolated masses may be provided singly or in arrays and, in the latter case, the molecular coatings may differ to provide qualitative and/or quantitative assays of a substance.

Research Organization:
LOCKHEED MARTIN ENERGY RES COR
DOE Contract Number:
AC05-96OR22464
Assignee:
U T Battelle, LLC (Oak Ridge, TN)
Patent Number(s):
US 6436346
OSTI ID:
874661
Country of Publication:
United States
Language:
English

References (2)

An integrated silicon thermopile as biosensor for the thermal monitoring of glucose, urea and penicillin journal January 1993
A vibrating probe thermal biochemical sensor journal January 1996

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