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Title: Analyte sensing mediated by adapter/carrier molecules

Patent ·
OSTI ID:874625

This invention relates to an improved method and system for sensing of one or more analytes. A host molecule, which serves as an adapter/carrier, is used to facilitate interaction between the analyte and the sensor element. A detectable signal is produced reflecting the identity and concentration of analyte present.

Assignee:
The Texas A&M University System (College Station, TX)
Patent Number(s):
US 6426231
Application Number:
09/441,376
OSTI ID:
874625
Country of Publication:
United States
Language:
English

References (35)

Porin mutants with new channel properties journal July 1998
Protein engineering and the development of generic biosensors journal April 1998
A,B,D,F-tetrasubstituted β-cyclodextrin as artificial channel compound journal January 1982
Complexation Thermodynamics of Cyclodextrins journal July 1998
Staphylococcal alpha-toxin: oligomerization of hydrophilic monomers to form amphiphilic hexamers induced through contact with deoxycholate detergent micelles. journal September 1981
Dynamics and Free Energy of Polymers Partitioning into a Nanoscale Pore journal January 1996
A biosensor that uses ion-channel switches journal June 1997
The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity journal April 1998
Novel Water-Soluble β-Cyclodextrin−Calix[4]arene Couples as Fluorescent Sensor Molecules for the Detection of Neutral Analytes journal August 1998
Multianalyte microspot immunoassay--microanalytical "compact disk" of the future journal November 1991
A sense for landmines journal July 1998
Characterization of individual polynucleotide molecules using a membrane channel journal November 1996
Crystal structure of the anthrax toxin protective antigen journal February 1997
Recognition of neutral species with synthetic receptors journal December 1997
Supported Membranes: Scientific and Practical Applications journal January 1996
Structure of Staphylococcal alpha -Hemolysin, a Heptameric Transmembrane Pore journal December 1996
Channel-type molecular structures. Part 4. Transmembrane transport of alkali-metal ions by ‘bouquet’ molecules journal January 1995
Building Doors into Cells journal September 1997
Molecular recognition of anions by synthetic receptors journal December 1997
Stochastic sensing of organic analytes by a pore-forming protein containing a molecular adapter journal April 1999
Towards Artificial Ion Channels: Transport of Alkali Metal Ions across Liposomal Membranes by“Bouquet” Molecules journal December 1992
Multiplexed biochemical assays with biological chips journal August 1993
Voltammetric responsive sensors for organic compounds based on organized self-assembled lipoyl-β-cyclodextrin derivative monolayer on a gold electrode journal January 1997
A simple method for the determination of the pore radius of ion channels in planar lipid bilayer membranes journal September 1992
Molecular structure and mechanisms of action of cyclic and linear ion transport antibiotics journal January 1996
Trends in odor intensity for human and electronic noses: Relative roles of odorant vapor pressure vs. molecularly specific odorant binding journal May 1998
The three-dimensional structure of bovine odorant binding protein and its mechanism of odor recognition journal November 1996
Introducing Chemical Transport Selectivity into Gold Nanotubule Membranes journal July 1998
Voltammetric study on a condensed monolayer of a long alkyl cyclodextrin derivative as a channel mimetic sensing membrane journal April 1993
Single-Molecule Spectroscopy and Dynamics at Room Temperature journal January 1996
α-Hemolysin fromStaphylococcus aureus:An Archetype of β-Barrel, Channel-Forming Toxins journal January 1998
Voltammetric anion responsive sensors based on modulation of ion permeability through Langmuir-Blodgett films containing synthetic anion receptors journal July 1990
The molecular elasticity of the extracellular matrix protein tenascin journal May 1998
Self-assembled α-hemolysin pores in an S-layer-supported lipid bilayer journal March 1998
Emerging techniques for investigating molecular interactions at lipid membranes journal November 1998