Methods for labeling .beta.-amyloid plaques and neurofibrillary tangles

Title: Methods for labeling .beta.-amyloid plaques and neurofibrillary tangles

Full Record
Other Related Research

Abstract

A method for labeling .beta.-amyloid plaques and neurofibrillary tangles in vivo and in vitro, comprises contacting a compound of formula (I): ##STR1## with mammalian tissue. In formula (I), R.sub.1 is selected from the group consisting of --C(O)-alkyl, --C(O)-alkylenyl-R.sub.4, --C(O)O-alkyl, --C(O)O-alkylenyl-R.sub.4, --C.dbd.C(CN).sub.2 -alkyl, --C.dbd.C(CN).sub.2 -alkylenyl-R.sub.4 , ##STR2## R.sub.4 is a radical selected from the group consisting of alkyl, substituted alkyl, aryl and substituted aryl; R.sub.5, is a radical selected from the group consisting of --NH.sub.2, --OH, --SH, --NH-alkyl, --NHR.sub.4, --NH-alkylenyl-R.sub.4, --O-alkyl, --O-alkylenyl-R.sub.4, --S-alkyl, and --S-alkylenyl-R.sub.4 ; R.sub.6 is a radical selected from the group consisting of --CN, --COOH, --C(O)O-alkyl, --C(O)O-alkylenyl-R.sub.4, --C(O)-alkyl, --C(O)-alkylenyl-R.sub.4, --C(O)-halogen, --C(O)NH , --C(O)NH-alkyl, --C(O)NH-alkylenyl-R.sub.4 ; R.sub.7 is a radical selected from the group consisting of O, NH, and S; and R.sub.8 is N, O or S. R.sub.2 and R.sub.3 are each independently selected from the group consisting of alkyl and alkylenyl-R.sub.10, wherein R.sub.10 is selected from the group consisting of --OH, --OTs, halogen, spiperone, spiperone ketal and spiperone-3-yl. Alternatively, R.sub.2 and R.sub.3 together form a heterocyclic ring, optionally substituted with at least one radical selected from the group consisting of alkyl, alkoxy, OH, OTs, halogen, alkylenyl-R.sub.10, carbonyl, spiperone, spiperone ketal and spiperone-3-yl. In the compounds of formula (I),more »« less

Inventors:

Barrio, Jorge R. ^[1]; Petric, Andrej ^[2]; Satyamurthy, Nagichettiar ^[3]; Small, Gary W. ^[3]; Cole, Gregory M. ^[4]; Huang, Sung-Cheng ^[5]

(Agoura Hills, CA)
(Ljubljana, SI)
(Los Angeles, CA)
(Santa Monica, CA)
(Sherman Oaks, CA)

Publication Date:: 2001-01-01

Research Org.:: University of California

OSTI Identifier:: 873929

Patent Number(s):: US 6274119

Assignee:: Regents of Univ. of California (Oakland, CA) OAK

DOE Contract Number:: FC03-87ER60615

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: methods; labeling; beta; -amyloid; plaques; neurofibrillary; tangles; method; vivo; vitro; comprises; contacting; compound; formula; str1; mammalian; tissue; selected; consisting; -c; -alkyl; -alkylenyl-r; o-alkyl; o-alkylenyl-r; dbd; cn; str2; radical; alkyl; substituted; aryl; -nh; -oh; -sh; -nh-alkyl; -nhr; -nh-alkylenyl-r; -o-alkyl; -o-alkylenyl-r; -s-alkyl; -s-alkylenyl-r; -cn; -cooh; -halogen; nh; nh-alkyl; nh-alkylenyl-r; independently; alkylenyl-r; 10; -ots; halogen; spiperone; ketal; spiperone-3-yl; alternatively; form; heterocyclic; optionally; alkoxy; oh; ots; carbonyl; compounds; hydrogen; carbon; atoms; replaced; radiolabel; radical selected; independently selected; comprises contacting; carbon atoms; carbon atom; mammalian tissue; optionally substituted; neurofibrillary tangles; substituted alkyl; -amyloid plaques; /424/

Citation Formats


                    Barrio, Jorge R., Petric, Andrej, Satyamurthy, Nagichettiar, Small, Gary W., Cole, Gregory M., and Huang, Sung-Cheng. Methods for labeling .beta.-amyloid plaques and neurofibrillary tangles.  United States: N. p., 2001. 
        Web.

Copy to clipboard


                    Barrio, Jorge R., Petric, Andrej, Satyamurthy, Nagichettiar, Small, Gary W., Cole, Gregory M., & Huang, Sung-Cheng. Methods for labeling .beta.-amyloid plaques and neurofibrillary tangles.  United States.

Copy to clipboard


                    Barrio, Jorge R., Petric, Andrej, Satyamurthy, Nagichettiar, Small, Gary W., Cole, Gregory M., and Huang, Sung-Cheng. Mon .  
        "Methods for labeling .beta.-amyloid plaques and neurofibrillary tangles".  United States.  https://www.osti.gov/servlets/purl/873929.

Copy to clipboard


                    
@article{osti_873929,

  title        = {Methods for labeling .beta.-amyloid plaques and neurofibrillary tangles},

  author       = {Barrio, Jorge R. and Petric, Andrej and Satyamurthy, Nagichettiar and Small, Gary W. and Cole, Gregory M. and Huang, Sung-Cheng},

  abstractNote = {A method for labeling .beta.-amyloid plaques and neurofibrillary tangles in vivo and in vitro, comprises contacting a compound of formula (I): ##STR1## with mammalian tissue. In formula (I), R.sub.1 is selected from the group consisting of --C(O)-alkyl, --C(O)-alkylenyl-R.sub.4, --C(O)O-alkyl, --C(O)O-alkylenyl-R.sub.4, --C.dbd.C(CN).sub.2 -alkyl, --C.dbd.C(CN).sub.2 -alkylenyl-R.sub.4 , ##STR2## R.sub.4 is a radical selected from the group consisting of alkyl, substituted alkyl, aryl and substituted aryl; R.sub.5, is a radical selected from the group consisting of --NH.sub.2, --OH, --SH, --NH-alkyl, --NHR.sub.4, --NH-alkylenyl-R.sub.4, --O-alkyl, --O-alkylenyl-R.sub.4, --S-alkyl, and --S-alkylenyl-R.sub.4 ; R.sub.6 is a radical selected from the group consisting of --CN, --COOH, --C(O)O-alkyl, --C(O)O-alkylenyl-R.sub.4, --C(O)-alkyl, --C(O)-alkylenyl-R.sub.4, --C(O)-halogen, --C(O)NH , --C(O)NH-alkyl, --C(O)NH-alkylenyl-R.sub.4 ; R.sub.7 is a radical selected from the group consisting of O, NH, and S; and R.sub.8 is N, O or S. R.sub.2 and R.sub.3 are each independently selected from the group consisting of alkyl and alkylenyl-R.sub.10, wherein R.sub.10 is selected from the group consisting of --OH, --OTs, halogen, spiperone, spiperone ketal and spiperone-3-yl. Alternatively, R.sub.2 and R.sub.3 together form a heterocyclic ring, optionally substituted with at least one radical selected from the group consisting of alkyl, alkoxy, OH, OTs, halogen, alkylenyl-R.sub.10, carbonyl, spiperone, spiperone ketal and spiperone-3-yl. In the compounds of formula (I), one or more of the hydrogen, halogen or carbon atoms can, optionally, be replaced with a radiolabel.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2001},

  month        = {1}

}

Copy to clipboard

Patent:

View Patent

Save / Share:

Export Metadata

Save to My Library

Similar records in OSTI.GOV collections:

Methods for labeling .beta.-amyloid plaques and neurofibrillary tangles

Patent Barrio, Jorge R. ; Petric, Andrej ; Satyamurthy, Nagichettiar ; ...

A method for labeling .beta.-amyloid plaques and neurofibrillary tangles in vivo and in vitro, comprises contacting a compound of formula (I): ##STR1## with mammalian tissue. In formula (I), R.sub.1 is selected from the group consisting of --C(O)-alkyl, --C(O)-alkylenyl-R.sub.4, --C(O)O-alkyl, --C(O)O-alkylenyl-R.sub.4, --C.dbd.C(CN).sub.2 -alkyl, --C.dbd.C(CN).sub.2 -alkylenyl-R.sub.4, ##STR2## R.sub.4 is a radical selected from the group consisting of alkyl, substituted alkyl, aryl and substituted aryl; R.sub.5 is a radical selected from the group consisting of --NH.sub.2, --OH, --SH, --NH-alkyl, --NHR.sub.4, --NH-alkylenyl-R.sub.4, --O-alkyl, --O-alkylenyl-R.sub.4, --S-alkyl, and --S-alkylenyl-R.sub.4 ; R.sub.6 is a radical selected from the group consisting of --CN, --COOH, --C(O)O-alkyl, --C(O)O-alkylenyl-R.sub.4, --C(O)-alkyl, --C(O)-alkylenyl-R.sub.4,more »« less
Full Text Available
Compositions for labeling .beta.-amyloid plaques and neurofibrillary tangles

Patent Barrio, Jorge R ; Petric, Andrej ; Satyamurthy, Nagichettiar ; ...

Compositions useful for labeling .beta.-amyloid plaques and neurofibrillary tangles are provided. The compositions comprises compounds of formula (I): ##STR00001## wherein R.sub.1 is selected from the group consisting of --C(O)-alkyl, --C(O)-alkylenyl-R.sub.4, --C(O)O-alkyl, --C(O)O-alkylenyl-R.sub.4, --C.dbd.C(CN).sub.2-alkyl, --C.dbd.C(CN).sub.2-alkylenyl-R.sub.4, ##STR00002## wherein R.sub.4 is a radical selected from the group consisting of alkyl, substituted alkyl, aryl and substituted aryl; R.sub.5 is a radical selected from the group consisting of --NH.sub.2, --OH, --SH, --NH-alkyl, --NHR.sub.4, --NH-alkylenyl-R.sub.4, --O-alkyl, --O-alkylenyl-R.sub.4, --S-alkyl, and --S-alkylenyl-R.sub.4; R.sub.6 is a radical selected from the group consisting of --CN, --COOH, --C(O)O-alkyl, --C(O)O-alkylenyl-R.sub.4, --C(O)-alkyl, --C(O)-alkylenyl-R.sub.4, --C(O)-halogen, --C(O)NH-alkyl, --C(O)NH-alkylenyl-R.sub.4 and --C(O)NH.sub.2; R.sub.7 is a radical selectedmore »« less
Full Text Available
Synthesis of [.sup.13C] and [.sup.2H] substituted methacrylic acid, [.sup.13C] and [.sup.2H] substituted methyl methacrylate and/or related compounds

Patent Alvarez, Marc A ; Martinez, Rodolfo A ; Unkefer, Clifford J

The present invention is directed to labeled compounds of the formulae ##STR00001## wherein Q is selected from the group consisting of --S--, --S(.dbd.O)--, and --S(.dbd.O).sub.2--, Z is selected from the group consisting of 1-naphthyl, substituted 1-naphthyl, 2-naphthyl, substituted 2-naphthyl, and phenyl groups with the structure ##STR00002## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are each independently selected from the group consisting of hydrogen, a C.sub.1-C.sub.4 lower alkyl, a halogen, and an amino group selected from the group consisting of NH.sub.2, NHR and NRR' where R and R' are each independently selected from the group consisting of a C.sub.1-C.sub.4 lower alkyl,more »« less
Full Text Available
Recyclable catalysts methods of making and using the same

Patent Dioumaev, Vladimir K. ; Bullock, R. Morris

Organometallic complexes are provided, which include a catalyst containing a transition metal, a ligand and a component having the formula GAr.sup.F. Ar.sup.F is an aromatic ring system selected from phenyl, naphthalenyl, anthracenyl, fluorenyl, or indenyl. The aromatic ring system has at least a substituent selected from fluorine, hydrogen, hydrocarbyl or fluorinated hydrocarbyl, G is substituted or unsubstituted (CH.sub.2).sub.n or (CF.sub.2).sub.n, wherein n is from 1 to 30, wherein further one or more CH.sub.2 or CF.sub.2 groups are optionally replaced by NR, PR, SiR.sub.2, BR, O or S, or R is hydrocarbyl or substituted hydrocarbyl, GAr.sup.F being covalently bonded to eithermore »« less
Full Text Available
Catalysts For Hydrogenation And Hydrosilylation Methods Of Making And Using The Same

Patent Dioumaev, Vladimir K. ; Bullock, R. Morris

A compound is provided including an organometallic complex represented by the formula I: wherein M is an atom of molybdenum or tangsten, Cp is substituted or unsubstituted cyclopentadienyl radical represented by the formula [C.sub.5 Q.sup.1 Q.sup.2 Q.sup.3 Q.sup.4 Q.sup.5 ], wherein Q.sup.1 to Q.sup.5 are independently selected from the group consisting of H radical, C.sub.1-20 hydrocarbyl radical, substituted hydrocarbyl radical, halogen radical, halogen-substituted hydrocarbyl radical, --OR, --C(O)R', --CO.sub.2 R', --SiR'.sub.3 and --NR'R", wherein R' and R" are independently selected from the group consisting of H radical, C.sub.1-20 hydrocarbyl radical, halogen radical, and halogen-substituted hydrocarbyl radical, wherein said Q.sup.1 to Q.sup.5more »« less
Full Text Available

Similar Records