Compositions for boron delivery to mammalian tissue

Patent · Mon Jan 01 00:00:00 EST 2001

OSTI ID:873928

Hawthorne, M Frederick ^[1]; Feaks, Debra Arlene ^[2]; Shelly, Kenneth John ^[2]

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1. Encino, CA
2. Los Angeles, CA

Boron neutron capture therapy can utilize X.sub.y B.sub.20 H.sub.17 L where X is an alkali metal, y is 1 to 4, and L is a two electron donor such as NH.sub.3, and Na.sub.2 B.sub.10 H.sub.9 NCO, among others. These borane salts may be used free or encapsulated in liposomes. Liposomes may also have embedded within their bilayers carboranes to increase the amount of delivered .sup.10 B and/or to increase the tumor specificity of the liposome.

• Research Organization: Univ. of California (United States)
• DOE Contract Number: FG03-95ER61975
• Assignee: Reagents of University of California (Oakland, CA)
• Patent Number(s): US 6274116
• OSTI ID: 873928
• Country of Publication: United States
• Language: English

Related Subjects

compositions
boron
delivery
mammalian
tissue
neutron
capture
therapy
utilize
20
17
alkali
metal
electron
donor
nh
na
10
nco
borane
salts
free
encapsulated
liposomes
embedded
bilayers
carboranes
increase
amount
delivered
tumor
specificity
liposome
alkali metal
neutron capture
boron neutron
capture therapy
electron donor
mammalian tissue
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