Compositions for boron delivery to mammalian tissue

Patent · 31 December 2000

OSTI ID:873928

Hawthorne, M Frederick ^[1]; Feaks, Debra Arlene ^[2]; Shelly, Kenneth John ^[2]

---

1. Encino, CA
2. Los Angeles, CA

Boron neutron capture therapy can utilize X.sub.y B.sub.20 H.sub.17 L where X is an alkali metal, y is 1 to 4, and L is a two electron donor such as NH.sub.3, and Na.sub.2 B.sub.10 H.sub.9 NCO, among others. These borane salts may be used free or encapsulated in liposomes. Liposomes may also have embedded within their bilayers carboranes to increase the amount of delivered .sup.10 B and/or to increase the tumor specificity of the liposome.

• Research Organization: University of California
• DOE Contract Number: FG03-95ER61975
• Assignee: Reagents of University of California (Oakland, CA)
• Patent Number(s): US 6274116
• OSTI ID: 873928
• Country of Publication: United States
• Language: English

Related Subjects

/424/
10
17
20
alkali
alkali metal
amount
bilayers
borane
boron
boron neutron
capture
capture therapy
carboranes
compositions
delivered
delivery
donor
electron
electron donor
embedded
encapsulated
free
increase
liposome
liposomes
mammalian
mammalian tissue
metal
na
nco
neutron
neutron capture
nh
salts
specificity
therapy
tissue
tumor
utilize