8-fluoropurine compounds

Barrio, Jorge R; Satyamurthy, Nagichettiar; Namavari, Mohammad; Phelps, Michael E

8-fluoropurine compounds

Patent · Sun Dec 31 23:00:00 EST 2000

OSTI ID:873863

Barrio, Jorge R ^[1]; Satyamurthy, Nagichettiar ^[2]; Namavari, Mohammad ^[2]; Phelps, Michael E ^[3]

Agoura Hills, CA
Los Angeles, CA
Encino, CA

An efficient, regiocontrolled approach to the synthesis of 8-fluoropurines by direct fluorination of purines with dilute elemental fluorine, or acetyl hypofluorite, is provided. In a preferred embodiment, a purine compound is dissolved in a polar solvent and reacted with a dilute mixture of F.sub.2 in He or other inert gas.

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Research Organization:: University of California

DOE Contract Number:: FC03-87ER60615

Assignee:: Regents of Univ. of California (Oakland, CA)

Patent Number(s):: US 6262254

OSTI ID:: 873863

Country of Publication:: United States

Language:: English

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8-fluoropurine compounds

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