Gastrin receptor-avid peptide conjugates

Hoffman, Timothy J; Volkert, Wynn A; Li, Ning; Sieckman, Gary; Higginbotham, C A

Gastrin receptor-avid peptide conjugates

Patent · Mon Jan 01 04:00:00 EST 2001

OSTI ID:873600

Hoffman, Timothy J ^[1]; Volkert, Wynn A ^[1]; Li, Ning ^[2]; Sieckman, Gary ^[3]; Higginbotham, C A ^[1]

Columbia, MO
Baltimore, MD
Ashland, MO

A compound for use as a therapeutic or diagnostic radiopharmaceutical includes a group capable of complexing a medically useful metal attached to a moiety which is capable of binding to a gastrin releasing peptide receptor. A method for treating a subject having a neoplastic disease includes administering to the subject an effective amount of a radiopharmaceutical having a metal chelated with a chelating group attached to a moiety capable of binding to a gastrin releasing peptide receptor expressed on tumor cells with subsequent internalization inside of the cell. A method of forming a therapeutic or diagnostic compound includes reacting a metal synthon with a chelating group covalently linked with a moiety capable of binding a gastrin releasing peptide receptor.

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Research Organization:: University of Missouri

DOE Contract Number:: FG02-89ER60875

Assignee:: Curators of University of Missouri (Columbia, MO)

Patent Number(s):: US 6200546

OSTI ID:: 873600

Country of Publication:: United States

Language:: English

References (46)

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