Method for sequential injection of liquid samples for radioisotope separations
- Richland, WA
- West Richland, WA
The present invention is a method of separating a short-lived daughter isotope from a longer lived parent isotope, with recovery of the parent isotope for further use. Using a system with a bi-directional pump and one or more valves, a solution of the parent isotope is processed to generate two separate solutions, one of which contains the daughter isotope, from which the parent has been removed with a high decontamination factor, and the other solution contains the recovered parent isotope. The process can be repeated on this solution of the parent isotope. The system with the fluid drive and one or more valves is controlled by a program on a microprocessor executing a series of steps to accomplish the operation. In one approach, the cow solution is passed through a separation medium that selectively retains the desired daughter isotope, while the parent isotope and the matrix pass through the medium. After washing this medium, the daughter is released from the separation medium using another solution. With the automated generator of the present invention, all solution handling steps necessary to perform a daughter/parent radionuclide separation, e.g. Bi-213 from Ac-225 "cow" solution, are performed in a consistent, enclosed, and remotely operated format. Operator exposure and spread of contamination are greatly minimized compared to the manual generator procedure described in U.S. patent application Ser. No. 08/789,973, now U.S. Pat. No. 5,749,042, herein incorporated by reference. Using 16 mCi of Ac-225 there was no detectable external contamination of the instrument components.
- Research Organization:
- Battelle Memorial Institute, Columbus, OH (United States)
- DOE Contract Number:
- AC06-76RL01830
- Assignee:
- Battelle Memorial Institute (Richland, WA)
- Patent Number(s):
- US 6153154
- OSTI ID:
- 873407
- Country of Publication:
- United States
- Language:
- English
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sequential
injection
liquid
samples
radioisotope
separations
separating
short-lived
daughter
isotope
lived
parent
recovery
bi-directional
pump
valves
solution
processed
generate
separate
solutions
contains
removed
decontamination
factor
recovered
process
repeated
fluid
drive
controlled
microprocessor
executing
series
steps
accomplish
operation
approach
cow
passed
separation
medium
selectively
retains
desired
matrix
pass
washing
released
automated
generator
handling
perform
radionuclide
bi-213
ac-225
performed
consistent
enclosed
remotely
operated
format
operator
exposure
spread
contamination
greatly
minimized
compared
manual
procedure
described
application
ser
08
789
973
749
042
incorporated
reference
16
mci
detectable
external
instrument
components
remotely operated
liquid sample
daughter isotope
liquid samples
decontamination factor
isotope separation
parent isotope
solution contains
application ser
fluid drive
bi-directional pump
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