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Opto-acoustic thrombolysis

Patent ·
OSTI ID:872842
 [1];  [2];  [3];  [4];  [3];  [5];  [3]
  1. Berkeley, CA
  2. Danville, CA
  3. Livermore, CA
  4. Orinda, CA
  5. Moss Beach, CA
+ Show Author Affiliations

This invention is a catheter-based device for generating an ultrasound excitation in biological tissue. Pulsed laser light is guided through an optical fiber to provide the energy for producing the acoustic vibrations. The optical energy is deposited in a water-based absorbing fluid, e.g. saline, thrombolytic agent, blood or thrombus, and generates an acoustic impulse in the fluid through thermoelastic and/or thermodynamic mechanisms. By pulsing the laser at a repetition rate (which may vary from 10 Hz to 100 kHz) an ultrasonic radiation field can be established locally in the medium. This method of producing ultrasonic vibrations can be used in vivo for the treatment of stroke-related conditions in humans, particularly for dissolving thrombus or treating vasospasm. The catheter can also incorporate thrombolytic drug treatments as an adjunct therapy and it can be operated in conjunction with ultrasonic detection equipment for imaging and feedback control and with optical sensors for characterization of thrombus type and consistency.

Research Organization:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA
DOE Contract Number:
W-7405-ENG-48
Assignee:
Regents of University of California (Oakland, CA)
Patent Number(s):
US 6022309
OSTI ID:
872842
Country of Publication:
United States
Language:
English

References (19)

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Bubble formation during pulsed laser ablation: mechanism and implications
  • van Leeuwen, Ton G. J. M.; Jansen, E. Duco; Motamedi, Massoud
  • OE/LASE'93: Optics, Electro-Optics, & Laser Applications in Science& Engineering, SPIE Proceedings https://doi.org/10.1117/12.147658
conference July 1993
Numerical studies of bubble dynamics in laser thrombolysis conference May 1996
Noncontact tissue ablation by Holmium: YSGG laser pulses in blood journal January 1991
Argon laser disintegration of thrombus and atherosclerotic plaque journal January 1984
Cavitation Bubble Dynamics and Acoustic Transient Generation in Ocular Surgery with Pulsed Neodymium:YAG Lasers journal October 1986
Preferential ablation of calcified arterial plaque with laser-induced plasmas journal October 1987
Human coronary laser recanalization: Human coronary laser recanalization journal July 1984
Initial clinical experience with a new pulsed dye laser device in angioplasty of limb ischemia and shunt fistula obstructions journal January 1992
Investigation of cavitation bubble dynamics using particle image velocimetry: implications for photoacoustic drug delivery conference May 1996
Visualization of microsecond laser ablation of porcine clot and gelatin under a clear liquid conference May 1996
Recanalization of arteries by laser radiation journal January 1984
Multispot laser photocoagulation system using a fiber bundle scanner journal January 1982
Feasibility of intravascular laser irradiation for in vivo visualization and therapy of cardiocirculatory diseases journal June 1982
Multifiber Optically-Shielded Catheter For Laser Angiosurgery conference April 1987
Laser coronary angioplasty: experience with 9 cadaver hearts journal December 1982
A new concept for a realtime feedback system in angioplasty with a flashlamp pumped dye laser journal January 1991
Effects of carbon dioxide, Nd-YAG, and argon laser radiation on coronary atheromatous plaques journal December 1982
Selective photothermolysis: precise microsurgery by selective absorption of pulsed radiation journal April 1983

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