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Title: Detection of biological molecules using boronate-based chemical amplification and optical sensors

Patent ·
OSTI ID:872763
 [1];  [2];  [3];  [4];  [5];  [6]
  1. Valencia, CA
  2. Los Angeles, CA
  3. Oakland, CA
  4. Pleasanton, CA
  5. Menlo Park, CA
  6. Livermore, CA
+ Show Author Affiliations

Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal.

Research Organization:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
DOE Contract Number:
W-7405-ENG-48
Assignee:
Regents of University of California (Oakland, CA); Minimed Inc. (Sylmar, CA)
Patent Number(s):
US 6002954
OSTI ID:
872763
Country of Publication:
United States
Language:
English

References (18)

Arylboronic Acids. VI. Aminoboronic Anhydrides and a New Heterocycle Containing Boron 1,2 journal August 1960
Purification and partial characterization of a mitogenic lectin from vicia sativa journal March 1979
Aldehyde Syntheses. Study of the preparation of 9,10-anthracenedicarboxaldehyde journal December 1979
Molecular Fluorescence Sensor for Saccharides Based on Amino Coumarin journal February 1995
Fluorescent chemosensors of carbohydrates. A means of chemically communicating the binding of polyols in water based on chelation-enhanced quenching journal July 1992
Determination of physiological levels of glucose in an aqueous matrix with digitally filtered Fourier transform near-infrared spectra journal July 1990
The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus journal September 1993
Quantitative determination of blood glucose using enzyme induced chemiluminescence of luminol journal March 1975
Development of the Implantable Glucose Sensor: What Are the Prospects and Why Is It Taking So Long? journal September 1995
Chiral discrimination of monosaccharides using a fluorescent molecular sensor journal March 1995
Fluorescence lifetime-based sensing of pH, Ca2+, K+ and glucose journal March 1993
Microporous membrane flow cell with nonimmobilized enzyme for chemiluminescent determination of glucose journal September 1982
pH gradient capillary zone electrophoresis using a solvent program delivery system journal February 1992
Sugar-Assisted Chirality Control of Tris(2,2′-bipyridine)-Metal Complexes journal July 1994
Near-infrared spectroscopic measurement of glucose in a protein matrix journal November 1993
Homovanillic acid as a fluorometric substrate for oxidative enzymes. Analytical applications of the peroxidase, glucose oxidase, and xanthine oxidase systems journal January 1968
Emerging biomedical and advanced applications of time-resolved fluorescence spectroscopy journal March 1994
Novel Saccharide-Photoinduced Electron Transfer Sensors Based on the Interaction of Boronic Acid and Amine journal September 1995

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Related Subjects

detection
biological
molecules
boronate-based
chemical
amplification
optical
sensors
methods
provided
determination
concentration
levels
polyhydroxylated
compounds
particularly
glucose
utilize
analyte
transducer
immobilized
polymeric
matrix
implantable
biocompatible
interrogation
produces
signal
capable
external
patient
quantitation
achieved
measurement
emitted
polymeric matrix
biological molecules
optical sensors
optical sensor
methods utilize
chemical amplification
particularly glucose
emitted signal
polyhydroxylated compounds
biological levels
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