Ultra-high-mass mass spectrometry with charge discrimination using cryogenic detectors
- Berkeley, CA
- Oakland, CA
- Danville, CA
An ultra-high-mass time-of-flight mass spectrometer using a cryogenic particle detector as an ion detector with charge discriminating capabilities. Cryogenic detectors have the potential for significantly improving the performance and sensitivity of time-of-flight mass spectrometers, and compared to ion multipliers they exhibit superior sensitivity for high-mass, slow-moving macromolecular ions and can be used as "stop" detectors in time-of-flight applications. In addition, their energy resolving capability can be used to measure the charge state of the ions. Charge discrimination is very valuable in all time-of-flight mass spectrometers. Using a cryogenically-cooled Nb-Al.sub.2 O.sub.3 -Nb superconductor-insulator-superconductor (SIS) tunnel junction (STJ) detector operating at 1.3 K as an ion detector in a time-of-flight mass spectrometer for large biomolecules it was found that the STJ detector has charge discrimination capabilities. Since the cryogenic STJ detector responds to ion energy and does not rely on secondary electron production, as in the conventionally used microchannel plate (MCP) detectors, the cryogenic detector therefore detects large molecular ions with a velocity-independent efficiency approaching 100%.
- Research Organization:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- DOE Contract Number:
- W-7405-ENG-48
- Assignee:
- Regents of University of California (Oakland, CA)
- Patent Number(s):
- US 5994694
- OSTI ID:
- 872715
- Country of Publication:
- United States
- Language:
- English
Cryogenic particle detectors
|
journal | March 1996 |
Simultaneous measurement of flight time and energy of large matrix-assisted laser desorption ionization ions with a superconducting tunnel junction detector
|
journal | October 1997 |
Biopolymer mass spectrometer with cryogenic particle detectors
|
journal | February 1996 |
Detection of single macromolecules using a cryogenic particle detector coupled to a biopolymer mass spectrometer
|
journal | June 1996 |
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mass
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charge
discrimination
cryogenic
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time-of-flight
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particle
detector
discriminating
capabilities
potential
significantly
improving
performance
sensitivity
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compared
multipliers
exhibit
superior
high-mass
slow-moving
macromolecular
stop
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addition
energy
resolving
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valuable
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nb-al
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superconductor-insulator-superconductor
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tunnel
junction
stj
operating
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rely
secondary
electron
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conventionally
microchannel
plate
mcp
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molecular
velocity-independent
efficiency
approaching
100
channel plate
time-of-flight mass
tunnel junction
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mass spectrometer
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microchannel plate
particle detector
secondary electron
significantly improving
flight mass
cryogenic particle
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cryogenic detectors
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