Combinatorial synthesis of novel materials

Schultz, Peter G; Xiang, Xiaodong; Goldwasser, Isy

Combinatorial synthesis of novel materials

Patent · Thu Dec 31 23:00:00 EST 1998

OSTI ID:872667

Schultz, Peter G ^[1]; Xiang, Xiaodong ^[2]; Goldwasser, Isy ^[2]

Oakland, CA
Alameda, CA

Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is generally prepared by delivering components of materials to predefined regions on a substrate, and simultaneously reacting the components to form at least two materials. Materials which can be prepared using the methods and apparatus of the present invention include, for example, covalent network solids, ionic solids and molecular solids. More particularly, materials which can be prepared using the methods and apparatus of the present invention include, for example, inorganic materials, intermetallic materials, metal alloys, ceramic materials, organic materials, organometallic materials, non-biological organic polymers, composite materials (e.g., inorganic composites, organic composites, or combinations thereof), etc. Once prepared, these materials can be screened for useful properties including, for example, electrical, thermal, mechanical, morphological, optical, magnetic, chemical, or other properties. Thus, the present invention provides methods for the parallel synthesis and analysis of novel materials having useful properties.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA

DOE Contract Number:: AC03-76SF00098

Assignee:: Regents of University of California (Oakland, CA); Symyx Technologies (Palo Alto, CA)

Patent Number(s):: US 5985356

OSTI ID:: 872667

Country of Publication:: United States

Language:: English

References (36)

The combinatorial synthesis and chemical and biological evaluation of a 1,4-benzodiazepine library. Bunin, B. A.; Plunkett, M. J.; Ellman, J. A. Proceedings of the National Academy of Sciences, Vol. 91, Issue 11 https://doi.org/10.1073/pnas.91.11.4708	journal	May 1994
Structural Chemistry and the Local Charge Picture of Copper Oxide Superconductors Cava, R. J. Science, Vol. 247, Issue 4943 https://doi.org/10.1126/science.247.4943.656	journal	February 1990
Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase Tuerk, C.; Gold, L. Science, Vol. 249, Issue 4968 https://doi.org/10.1126/science.2200121	journal	August 1990
Solid-State Chemistry: A A Rediscovered Chemical Frontier DiSalvo, F. J. Science, Vol. 247, Issue 4943 https://doi.org/10.1126/science.247.4943.649	journal	February 1990
Evaluation of peptide libraries: An iterative strategy to analyze the reactivity of peptide mixtures with antibodies Blake, James; Litzi-Davis, Leonora Bioconjugate Chemistry, Vol. 3, Issue 6 https://doi.org/10.1021/bc00018a008	journal	November 1992
Radio‐Frequency‐Sputtered Films of β‐Tungsten Structure Compounds Hanak, J. J.; Gittleman, J. I.; Pellicane, J. P. Journal of Applied Physics, Vol. 41, Issue 12 https://doi.org/10.1063/1.1658570	journal	November 1970
Strategies for epitope analysis using peptide synthesis Geysen, H. Mario; Rodda, Stuart J.; Mason, Tom J. Journal of Immunological Methods, Vol. 102, Issue 2 https://doi.org/10.1016/0022-1759(87)90085-8	journal	September 1987
A new type of synthetic peptide library for identifying ligand-binding activity Lam, Kit S.; Salmon, Sydney E.; Hersh, Evan M. Nature, Vol. 354, Issue 6348 https://doi.org/10.1038/354082a0	journal	November 1991
At the crossroads of chemistry and immunology: catalytic antibodies Lerner, R.; Benkovic, S.; Schultz, P. Science, Vol. 252, Issue 5006 https://doi.org/10.1126/science.2024118	journal	May 1991
Superconductivity at 93 K in a new mixed-phase Y-Ba-Cu-O compound system at ambient pressure Wu, M. K.; Ashburn, J. R.; Torng, C. J. Physical Review Letters, Vol. 58, Issue 9 https://doi.org/10.1103/PhysRevLett.58.908	journal	March 1987
Low temperature linear magnetic field sensor based on magnetoresistance of the perovskite oxide La–Sr–Co–O Mahendiran, R.; Raychaudhuri, A. K.; Chainani, A. Review of Scientific Instruments, Vol. 66, Issue 4 https://doi.org/10.1063/1.1146446	journal	April 1995
Peptides on phage: a vast library of peptides for identifying ligands Cwirla, S. E.; Peters, E. A.; Barrett, R. W. Proceedings of the National Academy of Sciences, Vol. 87, Issue 16, p. 6378-6382 https://doi.org/10.1073/pnas.87.16.6378	journal	August 1990
Generation and screening of an oligonucleotide-encoded synthetic peptide library. Needels, M. C.; Jones, D. G.; Tate, E. H. Proceedings of the National Academy of Sciences, Vol. 90, Issue 22 https://doi.org/10.1073/pnas.90.22.10700	journal	November 1993
Assembly of combinatorial antibody libraries on phage surfaces: the gene III site. Barbas, C. F.; Kang, A. S.; Lerner, R. A. Proceedings of the National Academy of Sciences, Vol. 88, Issue 18 https://doi.org/10.1073/pnas.88.18.7978	journal	September 1991
A Class of Cobalt Oxide Magnetoresistance Materials Discovered with Combinatorial Synthesis Brice o., G.; Chang, H.; Sun, X. Science, Vol. 270, Issue 5234 https://doi.org/10.1126/science.270.5234.273	journal	October 1995
Complex synthetic chemical libraries indexed with molecular tags Ohlmeyer, M. H.; Swanson, R. N.; Dillard, L. W. Proceedings of the National Academy of Sciences, Vol. 90, Issue 23 https://doi.org/10.1073/pnas.90.23.10922	journal	December 1993
Searching for peptide ligands with an epitope library Scott, J.; Smith, G. Science, Vol. 249, Issue 4967 https://doi.org/10.1126/science.1696028	journal	July 1990
Light-directed, spatially addressable parallel chemical synthesis Fodor, S.; Read, J.; Pirrung, M. Science, Vol. 251, Issue 4995 https://doi.org/10.1126/science.1990438	journal	February 1991
A New High- T _c Oxide Superconductor without a Rare Earth Element Maeda, Hiroshi; Tanaka, Yoshiaki; Fukutomi, Masao Japanese Journal of Applied Physics, Vol. 27, Issue Part 2, No. 2 https://doi.org/10.1143/JJAP.27.L209	journal	February 1988
The ?multiple-sample concept? in materials research: Synthesis, compositional analysis and testing of entire multicomponent systems Hanak, J. J. Journal of Materials Science, Vol. 5, Issue 11 https://doi.org/10.1007/BF00558177	journal	November 1970
Compositional Determination of rf Co-Sputtered Multicomponent Systems Hanak, J. J. Journal of Vacuum Science and Technology, Vol. 8, Issue 1 https://doi.org/10.1116/1.1316278	journal	January 1971
Possible highT c superconductivity in the Ba?La?Cu?O system Bednorz, J. G.; M�ller, K. A. Zeitschrift f�r Physik B Condensed Matter, Vol. 64, Issue 2 https://doi.org/10.1007/BF01303701	journal	June 1986
Thousandfold Change in Resistivity in Magnetoresistive La-Ca-Mn-O Films Jin, S.; Tiefel, T. H.; McCormack, M. Science, Vol. 264, Issue 5157 https://doi.org/10.1126/science.264.5157.413	journal	April 1994
In vitro selection of RNA molecules that bind specific ligands Ellington, Andrew D.; Szostak, Jack W. Nature, Vol. 346, Issue 6287 https://doi.org/10.1038/346818a0	journal	August 1990
Random peptide libraries: a source of specific protein binding molecules Devlin, J.; Panganiban, L.; Devlin, P. Science, Vol. 249, Issue 4967 https://doi.org/10.1126/science.2143033	journal	July 1990
Catalytic antibodies Tramontano, A.; Janda, K.; Lerner, R. Science, Vol. 234, Issue 4783 https://doi.org/10.1126/science.3787261	journal	December 1986
Selective chemical catalysis by an antibody Pollack, S.; Jacobs, J.; Schultz, P. Science, Vol. 234, Issue 4783 https://doi.org/10.1126/science.3787262	journal	December 1986
Chemistry of High-Temperature Superconductors Sleight, A. W. Science, Vol. 242, Issue 4885 https://doi.org/10.1126/science.242.4885.1519	journal	December 1988
Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery Houghten, Richard A.; Pinilla, Clemencia; Blondelle, Sylvie E. Nature, Vol. 354, Issue 6348 https://doi.org/10.1038/354084a0	journal	November 1991
High-pressure study of the new Y-Ba-Cu-O superconducting compound system Hor, P. H.; Gao, L.; Meng, R. L. Physical Review Letters, Vol. 58, Issue 9 https://doi.org/10.1103/PhysRevLett.58.911	journal	March 1987
The effect of grain size on the superconducting transition temperature of the transition metals Hanak, J. J.; Gittleman, J. I.; Pellicane, J. P. Physics Letters A, Vol. 30, Issue 3 https://doi.org/10.1016/0375-9601(69)90936-0	journal	October 1969
Magnetoresistance in Metallic Crystals of La _{1- x} Sr _x CoO ₃ Yamaguchi, Shinya; Taniguchi, Hirohisa; Takagi, Hidenori Journal of the Physical Society of Japan, Vol. 64, Issue 6 https://doi.org/10.1143/JPSJ.64.1885	journal	June 1995
Electroluminescence in ZnS: Mn _x : Cu _y rf–Sputtered Films Hanak, J. J. Japanese Journal of Applied Physics, Vol. 13, Issue S1 https://doi.org/10.7567/JJAPS.2S1.809	journal	January 1974
The simultaneous multiple production of solution phase peptides; assessment of the geysen method of simultaneous peptide synthesis. Bray, Andrew M.; Joe Maeji, N.; Mario Geysen, H. Tetrahedron Letters, Vol. 31, Issue 40 https://doi.org/10.1016/S0040-4039(00)97966-8	journal	January 1990
Calculation of composition of dilute cosputtered multicomponent films Hanak, J. J.; Bolker, B. F. T. Journal of Applied Physics, Vol. 44, Issue 11 https://doi.org/10.1063/1.1662105	journal	November 1973
Magnetic compounds wtth perovskite structure III. ferromagnetic compounds of cobalt Jonker, G. H.; Van Santen, J. H. Physica, Vol. 19, Issue 1-12 https://doi.org/10.1016/S0031-8914(53)80011-X	journal	January 1953

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Combinatorial synthesis of novel materials

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