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Specimen illumination apparatus with optical cavity for dark field illumination

Patent ·
OSTI ID:872657
 [1];  [1];  [2]
  1. Walnut Creek, CA
  2. Lafayette, CA
+ Show Author Affiliations
An illumination apparatus with a specimen slide holder, an illumination source, an optical cavity producing multiple reflection of illumination light to a specimen comprising a first and a second reflective surface arranged to achieve multiple reflections of light to a specimen is provided. The apparatus can further include additional reflective surfaces to achieve the optical cavity, a slide for mounting the specimen, a coverslip which is a reflective component of the optical cavity, one or more prisms for directing light within the optical cavity, antifading solutions for improving the viewing properties of the specimen, an array of materials for analysis, fluorescent components, curved reflective surfaces as components of the optical cavity, specimen detection apparatus, optical detection equipment, computers for analysis of optical images, a plane polarizer, fiberoptics, light transmission apertures, microscopic components, lenses for viewing the specimen, and upper and lower mirrors above and below the specimen slide as components of the optical cavity. Methods of using the apparatus are also provided.
Research Organization:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA
DOE Contract Number:
W-7405-ENG-48
Assignee:
Regents of University of California (Oakland, CA)
Patent Number(s):
US 5982534
OSTI ID:
872657
Country of Publication:
United States
Language:
English

References (5)

Fluorescence array detector for large-field quantitative fluorescence cytometry journal July 1994
Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors journal October 1992
Matrix DNA Hybridization journal April 1993
Light-directed, spatially addressable parallel chemical synthesis journal February 1991
Extensive polymorphisms observed in HIV–1 clade B protease gene using high–density oligonucleotide arrays journal July 1996

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Related Subjects

/359/422/435/999/
achieve
additional
analysis
antifading
apertures
apparatus
arranged
array
below
cavity
component
components
comprising
computers
coverslip
curved
curved reflective
dark
dark field
detection
detection apparatus
detection equipment
directing
directing light
equipment
fiberoptics
field
fluorescent
holder
illumination
illumination apparatus
illumination light
illumination source
images
improving
lenses
light
light transmission
materials
methods
microscopic
mirrors
mounting
multiple
multiple reflection
multiple reflections
optical
optical cavity
optical detection
optical image
optical images
plane
polarizer
prisms
producing
producing multiple
properties
provided
reflection
reflections
reflective
reflective surface
reflective surfaces
slide
solutions
source
specimen
specimen comprising
surface
surfaces
transmission
upper
viewing