Crystallization of M-CSF.alpha.

Pandit, Jayvardhan; Jancarik, Jarmila; Kim, Sung-Hou; Koths, Kirston; Halenbeck, Robert; Fear, Anna Lisa; Taylor, Eric; Yamamoto, Ralph; Bohm, Andrew

Title: Crystallization of M-CSF.alpha.

Patent · Fri Jan 01 00:00:00 EST 1999

OSTI ID:872125

Pandit, Jayvardhan ^[1]; Jancarik, Jarmila ^[2]; Kim, Sung-Hou ^[3]; Koths, Kirston ^[4]; Halenbeck, Robert ^[5]; Fear, Anna Lisa ^[6]; Taylor, Eric ^[6]; Yamamoto, Ralph ^[7]; Bohm, Andrew ^[8]

Mystic, CT
Walnut Creek, CA
Moraga, CA
El Cerrito, CA
San Rafael, CA
Oakland, CA
Martinez, CA
Berkeley, CA

The present invention is directed to methods for crystallizing macrophage colony stimulating factor (M-CSF) and to a crystalline M-CSF produced thereby. The present invention is also directed to methods for designing and producing M-CSF agonists and antagonists using information derived from the crystallographic structure of M-CSF. The invention is also directed to methods for screening M-CSF agonists and antagonists. In addition, the present invention is directed to an isolated, purified, soluble and functional M-CSF receptor.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

DOE Contract Number:: AC03-76SF00098

Assignee:: Chiron Corporation (Emeryville, CA)

Patent Number(s):: US 5866114

OSTI ID:: 872125

Country of Publication:: United States

Language:: English

References (17)

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Three-dimensional structure of dimeric human recombinant macrophage colony-stimulating factor Pandit, J.; Bohm, A.; Jancarik, J. Science, Vol. 258, Issue 5086 https://doi.org/10.1126/science.1455231	journal	November 1992
[48] Protein crystallization Ollis, David; White, Stephen Methods in Enzymology https://doi.org/10.1016/0076-6879(90)82050-C	book	January 1990
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Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule Cunningham, B.; Ultsch, M.; De Vos, A. Science, Vol. 254, Issue 5033 https://doi.org/10.1126/science.1948064	journal	November 1991
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Title: Crystallization of M-CSF.alpha.

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