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Title: Hydroxyalkyl phosphine gold complexes for use as diagnostic and therapeutic pharmaceuticals and method of making same

Patent ·
OSTI ID:872011
 [1];  [1];  [1];  [1]
  1. Columbia, MO
+ Show Author Affiliations

A complex and method for making same for use as a diagnostic or therapeutic pharmaceutical includes a ligand comprising at least one hydroxyalkyl phosphine donor group bound to a gold atom to form a gold-ligand complex that is stable in aqueous solutions containing oxygen, serum and other body fluids.

Research Organization:
Univ. of Missouri, Columbia, MO (United States)
DOE Contract Number:
FG02-89ER60875
Assignee:
Curators of University of Missouri (Columbia, MO)
Patent Number(s):
US 5843993
OSTI ID:
872011
Country of Publication:
United States
Language:
English

References (19)

In vitro and in vivo characterization of a 99mTc complex with tris(hydroxymethyl)phosphine (THP) journal July 1996
Chiral Phosphine Ligands Derived from Sugars. 3. Syntheses, Structures, and Spectroscopic Properties of Gold(I) Complexes with Chiral Phosphines from Glucose. X-ray Structures of [Au(2-MBPA)Cl] and [Au(3-MBPA)(2-pyS)] journal January 1996
Stable gold( I ) complexes with chelate rings: solution studies of bis(phosphino)ethane complexes and X-ray crystal structure of bis[1,2-bis(diphenylphosphino)ethane]gold( I ) hexafluoroantimonate–acetone (1/1) journal January 1984
Medicinal chemistry and pharmacology of gold compounds journal August 1996
Relativistic effects on chemical properties journal August 1979
MISSYM 1.1 – a flexible new release journal December 1988
Nearly regular tetrahedral geometry in a gold(I)-phosphine complex. X-Ray crystal structure of tetrakis(methyldiphenylphosphine)gold(I) hexafluorophosphate journal January 1981
An empirical correction for absorption anisotropy journal January 1995
Ludwig Mond Lecture. High-carat gold compounds journal January 1995
Synthesis of water-soluble (tri(hydroxymethyl)phosphine)gold(I) complexes containing a nucleoside ligand journal March 1994
A tetrahedral complex of gold(I). The crystal and molecular structure of Au(Ph2PCH2CH2PPh2)2Cl·2H2O journal January 1984
NRCVAX – an interactive program system for structure analysis journal August 1989
Vehicles, Chelators, and Radionuclides:  Choosing the “Building Blocks” of an Effective Therapeutic Radioimmunoconjugate journal January 1996
Hydroxymethyl bis(phosphines) and their palladium(II) and platinum(II) complexes formed via biphasic reactions. Crystal structure of [Pd{(HOH2C)2PC6H4P(CH2OH)2}2]Cl2 journal January 1996
Chemistry in Environmentally Benign Media. 3. 1 Synthesis and Characterization of Rhenium(V) Complexes Derived from Novel Water-Soluble (Hydroxymethyl)phosphines. Crystal Structures of [Re(O) 2 {(HOH 2 C) 2 PC 6 H 4 P(CH 2 OH) 2 } 2 ]I and [Re(O) 2 {(HOH 2 C) 2 PCH 2 CH 2 P(CH 2 OH) 2 } 2 ]Cl journal January 1996
Crystal structures and solution electronic absorption and MCD spectra for perchlorate and halide salts of binuclear gold(I) complexes containing bridging Me2PCH2PMe2 (dmpm) or Me2PCH2CH2PMe2 (dmpe) ligands journal March 1989
Relativistic effects in structural chemistry journal May 1988
Syntheses and Structural Characterization of Tetrahedral Four-Coordinate Gold(I) Complexes of 1,3,5-Triaza-7-phosphaadamantane. An Example of a Hydrogen-Bond-Directed Supramolecular Assembly journal January 1996
Application of a segment description of the unique set of reflections to data collection and data reduction journal October 1979

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hydroxyalkyl
phosphine
gold
complexes
diagnostic
therapeutic
pharmaceuticals
method
complex
pharmaceutical
ligand
comprising
donor
bound
atom
form
gold-ligand
stable
aqueous
solutions
containing
oxygen
serum
fluids
therapeutic pharmaceutical
hydroxyalkyl phosphine
aqueous solution
aqueous solutions
solutions containing
containing oxygen
phosphine donor
therapeutic pharmaceuticals
ligand comprising
ligand complex
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