Amino acid analogs for tumor imaging
- Atlanta, GA
- Decatur, GA
The invention provides novel amino acid compounds of use in detecting and evaluating brain and body tumors. These compounds combine the advantageous properties of 1-amino-cycloalkyl-1-carboxylic acids, namely, their rapid uptake and prolonged retention in tumors with the properties of halogen substituents, including certain useful halogen isotopes including fluorine-18, iodine-123, iodine-125, iodine-131, bromine-75, bromine-76, bromine-77 and bromine-82. In one aspect, the invention features amino acid compounds that have a high specificity for target sites when administered to a subject in vivo. Preferred amino acid compounds show a target to non-target ratio of at least 5:1, are stable in vivo and substantially localized to target within 1 hour after administration. An especially preferred amino acid compound is ›.sup.18 F!-1-amino-3-fluorocyclobutane-1-carboxylic acid (FACBC). In another aspect, the invention features pharmaceutical compositions comprised of an .alpha.-amino acid moiety attached to either a four, five, or a six member carbon-chain ring. In addition, the invention features analogs of .alpha.-aminoisobutyric acid.
- Research Organization:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN
- DOE Contract Number:
- FG05-93ER61737
- Assignee:
- Emory University (Atlanta, GA)
- Patent Number(s):
- US 5808146
- Application Number:
- 08/554906
- OSTI ID:
- 871844
- Country of Publication:
- United States
- Language:
- English
Direct synthesis of .alpha.-halogenomethyl-.alpha.-amino acids from the parent .alpha.-amino acids
|
journal | July 1979 |
Radiopharmaceuticals II: Proceedings 2nd International Symposium on Radiopharmaceuticals, March 19–22, 1979, Seattle, Washington
|
journal | December 1980 |
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Amino acid analogs for tumor imaging
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1-amino-cycloalkyl-1-carboxylic
18
acid
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acid moiety
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addition
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advantageous
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alpha
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bromine-76
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