Optical reaction cell and light source for ›18F! fluoride radiotracer synthesis

Ferrieri, Richard A; Schlyer, David; Becker, Richard J

Optical reaction cell and light source for ›18F! fluoride radiotracer synthesis

Patent · Tue Sep 15 00:00:00 EDT 1998

OSTI ID:871843

Ferrieri, Richard A ^[1]; Schlyer, David ^[2]; Becker, Richard J ^[3]

Patchogue, NY
Bellport, NY
Islip, NY

Apparatus for performing organic synthetic reactions, particularly no-carrier-added nucleophilic radiofluorination reactions for PET radiotracer production. The apparatus includes an optical reaction cell and a source of broadband infrared radiant energy, which permits direct coupling of the emitted radiant energy with the reaction medium to heat the reaction medium. Preferably, the apparatus includes means for focusing the emitted radiant energy into the reaction cell, and the reaction cell itself is preferably configured to reflect transmitted radiant energy back into the reaction medium to further improve the efficiency of the apparatus. The apparatus is well suited to the production of high-yield syntheses of 2-›.sup.18 F!fluoro-2-deoxy-D-glucose. Also provided is a method for performing organic synthetic reactions, including the manufacture of ›.sup.18 F!-labeled compounds useful as PET radiotracers, and particularly for the preparation of 2-›.sup.18 F!fluoro-2-deoxy-D-glucose in higher yields than previously possible.

Research Organization:: ASSOC UNIVERSITIES INC

DOE Contract Number:: AC02-76CH00016

Assignee:: Associated Universities, Inc. (Washington, DC)

Patent Number(s):: US 5808020

Application Number:: 08/694,398

OSTI ID:: 871843

Country of Publication:: United States

Language:: English

References (10)

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Back-to-back “one-pot” [18F]FDG syntheses in a single Siemens-CTI chemistry process control unit Mock, Bruce H.; Vavrek, Michael T.; Mulholland, G. Keith Nuclear Medicine and Biology, Vol. 23, Issue 4 https://doi.org/10.1016/0969-8051(96)00030-3	journal	May 1996
Synthesis of 14 (R,S)-[18F]fluoro-6-thia-heptadecanoic acid (FTHA) Degrado, Timothy R. Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 29, Issue 9 https://doi.org/10.1002/jlcr.2580290903	journal	September 1991
Recommendation for a practical production of [2-18F]fluoro-2-deoxy-D-glucose Coenen, H. H.; Pike, V. W.; Stöcklin, G. International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 38, Issue 8 https://doi.org/10.1016/0883-2889(87)90124-9	journal	January 1987
An improved synthesis of no-carrier-added (NCA) 6-[18F]Fluoro-l-DOPA and its remote routine production for PET investigations of dopaminergic systems Reddy, Guvvala N.; Haeberli, Marc; Beer, Hans-Frieder Applied Radiation and Isotopes, Vol. 44, Issue 4 https://doi.org/10.1016/0969-8043(93)90126-U	journal	April 1993
Computer-aided synthesis (CAS) of no-carrier-added 2-[18F]Fluoro-2-deoxy-d-glucose: an efficient automated system for the aminopolyether-supported nucleophilic fluorination Hamacher, K.; Blessing, G.; Nebeling, B. International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 41, Issue 1 https://doi.org/10.1016/0883-2889(90)90129-5	journal	January 1990
Electrochemical cell design for in-situ IR study of reactions involving high electric current and gas evolution Zhang, Jiujun; Lu, Juntao; Cha, Chuansin Journal of Electroanalytical Chemistry and Interfacial Electrochemistry, Vol. 265, Issue 1-2 https://doi.org/10.1016/0022-0728(89)80203-7	journal	June 1989
An improved infrared cell reactor for use in transient response studies: The catalytic oxidation of CO reexamined Nagai, M. Journal of Catalysis, Vol. 101, Issue 2 https://doi.org/10.1016/0021-9517(86)90280-0	journal	October 1986
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Optical reaction cell and light source for ›18F! fluoride radiotracer synthesis

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