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Ultrashort pulse high repetition rate laser system for biological tissue processing

Patent ·
OSTI ID:871382
 [1];  [2];  [3];  [4];  [5];  [4];  [4];  [4]
  1. Laguna Beach, CA
  2. Danville, CA
  3. Moss Beach, CA
  4. Livermore, CA
  5. Fremont, CA
+ Show Author Affiliations
A method and apparatus is disclosed for fast, efficient, precise and damage-free biological tissue removal using an ultrashort pulse duration laser system operating at high pulse repetition rates. The duration of each laser pulse is on the order of about 1 fs to less than 50 ps such that energy deposition is localized in a small depth and occurs before significant hydrodynamic motion and thermal conduction, leading to collateral damage, can take place. The depth of material removed per pulse is on the order of about 1 micrometer, and the minimal thermal and mechanical effects associated with this ablation method allows for high repetition rate operation, in the region 10 to over 1000 Hertz, which, in turn, achieves high material removal rates. The input laser energy per ablated volume of tissue is small, and the energy density required to ablate material decreases with decreasing pulse width. The ablation threshold and ablation rate are only weakly dependent on tissue type and condition, allowing for maximum flexibility of use in various biological tissue removal applications. The use of a chirped-pulse amplified Titanium-doped sapphire laser is disclosed as the source in one embodiment.
Research Organization:
University of California
DOE Contract Number:
FG03-91ER61227
Assignee:
Regents of University of California (Oakland, CA)
Patent Number(s):
US 5720894
OSTI ID:
871382
Country of Publication:
United States
Language:
English

References (14)

Investigation and spectral analysis of the plasma-induced ablation mechanism of dental hydroxyapatite journal April 1994
Damage Threshold as a Function of Pulse Duration in Biological Tissue book January 1994
Application of ultrashort laser pulses in dentistry conference December 1993
Plasma-mediated ablation of brain tissue with picosecond laser pulses journal June 1994
Laser-Induced Damage in Dielectrics with Nanosecond to Subpicosecond Pulses journal March 1995
Laser‐induced breakdown by impact ionization in SiO 2 with pulse widths from 7 ns to 150 fs journal June 1994
Femtosecond-pulse laser ablation of human corneas journal May 1994
Ablation of hard dental tissues with an ArF-pulsed excimer laser
  • Neev, Joseph; Raney, Daniel; Whalen, William E.
  • Optics, Electro-Optics, and Laser Applications in Science and Engineering, SPIE Proceedings https://doi.org/10.1117/12.44100
conference June 1991
Effect of water content on UV and IR hard tissue ablation conference January 1995
Influence of the laser-spot diameter on photo-ablation rates journal January 1995
Femtosecond pulse laser ablation of metallic, semiconducting, ceramic, and biological materials conference September 1994
Scanning electron microscopy and thermal characteristics of dentin ablated by a short-pulse XeCl excimer laser journal January 1993
Time resolved dynamics of subpicosecond laser ablation journal June 1993
Nanosecond and femtosecond excimer laser ablation of fused silica journal April 1992

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/216/156/606/607/
10
1000
50
ablate
ablate material
ablated
ablation
achieves
allowing
allows
amplified
apparatus
applications
associated
biological
biological tissue
chirped-pulse
collateral
condition
conduction
damage
damage-free
decreases
decreasing
density
dependent
deposition
depth
disclosed
duration
effects
efficient
embodiment
energy
energy density
energy deposition
fast
flexibility
fs
hertz
hydrodynamic
input
input laser
laser
laser energy
laser pulse
leading
localized
material
material removal
material removed
maximum
mechanical
method
method allow
method allows
micrometer
minimal
minimal thermal
motion
occurs
operating
operation
precise
processing
pulse
pulse duration
pulse repetition
pulse width
rate
rate laser
rate operation
rates
region
removal
removal rate
removal rates
removed
repetition
repetition rate
repetition rates
required
sapphire
sapphire laser
significant
source
thermal
thermal conduction
threshold
tissue
titanium-doped
type
ultrashort
ultrashort pulse
various
various biological
volume
weakly
width