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Methodology and apparatus for diffuse photon mimaging

Patent ·
OSTI ID:871264
 [1];  [1];  [1]
  1. Los Angeles, CA
+ Show Author Affiliations

Non-invasive near infrared optical medical imaging devices for both hematoma detection in the brain and early tumor detection in the breast is achieved using image reconstruction which allows a mapping of the position dependent contrast diffusive propagation constants, which are related to the optical absorption coefficient and scattering coefficient in the tissue, at near infrared wavelengths. Spatial resolutions in the range of 5 mm for adult brain sizes and breast sizes can be achieved. The image reconstruction utilizes WKB approximation on most probable diffusion paths which has as lowest order approximation the straight line-of-sight between the plurality of sources and the plurality of detectors. The WKB approximation yields a set of linear equations in which the contrast optical absorption coefficients are the unknowns and for which signals can be generated to produce a pixel map of the contrast optical resolution of the scanned tissue.

Research Organization:
University of California
Sponsoring Organization:
USDOE - Office of Energy Research (ER)
DOE Contract Number:
FG03-88ER45378
Assignee:
Regents of University of California (Oakland, CA)
Patent Number(s):
US 5694938
OSTI ID:
871264
Country of Publication:
United States
Language:
English

References (4)

Near-infrared absorption imaging of dense scattering media by steady-state diffusion tomography
  • Graber, Harry L.; Chang, Jeng-Hua; Lubowsky, Jack
  • OE/LASE'93: Optics, Electro-Optics, & Laser Applications in Science& Engineering, SPIE Proceedings https://doi.org/10.1117/12.154656
conference September 1993
Time-Resolved Imaging of Translucent Droplets in Highly Scattering Turbid Media journal June 1994
Photon hitting density journal January 1993
Iterative reconstruction of near-infrared absorption images conference December 1992

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