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Title: Polypeptide having an amino acid replaced with N-benzylglycine

Abstract

The present invention relates to one or more polypeptides having useful biological activity in a mammal, which comprise: a polypeptide related to bradykinin of four to ten amino acid residues wherein one or more specific amino acids in the polypeptide chain are replaced with achiral N-benzylglycine. These polypeptide analogues have useful potent agonist or antagonist pharmacological properties depending upon the structure. A preferred polypeptide is (N-benzylglycine.sup.7)-bradykinin.

Inventors:
 [1];  [2]
  1. Livermore, CA
  2. Los Angeles, CA
Publication Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
OSTI Identifier:
870479
Patent Number(s):
US 5527882
Assignee:
Regents of University of California (Alameda, CA)
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
polypeptide; amino; acid; replaced; n-benzylglycine; relates; polypeptides; useful; biological; activity; mammal; comprise; related; bradykinin; residues; specific; acids; chain; achiral; analogues; potent; agonist; antagonist; pharmacological; properties; depending; structure; preferred; -bradykinin; amino acid; amino acids; acid residues; acid residue; /530/

Citation Formats

Mitchell, Alexander R, and Young, Janis D. Polypeptide having an amino acid replaced with N-benzylglycine. United States: N. p., 1996. Web.
Mitchell, Alexander R, & Young, Janis D. Polypeptide having an amino acid replaced with N-benzylglycine. United States.
Mitchell, Alexander R, and Young, Janis D. Mon . "Polypeptide having an amino acid replaced with N-benzylglycine". United States. https://www.osti.gov/servlets/purl/870479.
@article{osti_870479,
title = {Polypeptide having an amino acid replaced with N-benzylglycine},
author = {Mitchell, Alexander R and Young, Janis D},
abstractNote = {The present invention relates to one or more polypeptides having useful biological activity in a mammal, which comprise: a polypeptide related to bradykinin of four to ten amino acid residues wherein one or more specific amino acids in the polypeptide chain are replaced with achiral N-benzylglycine. These polypeptide analogues have useful potent agonist or antagonist pharmacological properties depending upon the structure. A preferred polypeptide is (N-benzylglycine.sup.7)-bradykinin.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1996},
month = {1}
}

Patent:

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