Polypeptide having an amino acid replaced with N-benzylglycine
Patent
·
OSTI ID:870479
- Livermore, CA
- Los Angeles, CA
The present invention relates to one or more polypeptides having useful biological activity in a mammal, which comprise: a polypeptide related to bradykinin of four to ten amino acid residues wherein one or more specific amino acids in the polypeptide chain are replaced with achiral N-benzylglycine. These polypeptide analogues have useful potent agonist or antagonist pharmacological properties depending upon the structure. A preferred polypeptide is (N-benzylglycine.sup.7)-bradykinin.
- Research Organization:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- Assignee:
- Regents of University of California (Alameda, CA)
- Patent Number(s):
- US 5527882
- OSTI ID:
- 870479
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
polypeptide
amino
acid
replaced
n-benzylglycine
relates
polypeptides
useful
biological
activity
mammal
comprise
related
bradykinin
residues
specific
acids
chain
achiral
analogues
potent
agonist
antagonist
pharmacological
properties
depending
structure
preferred
-bradykinin
amino acid
amino acids
acid residues
acid residue
/530/
amino
acid
replaced
n-benzylglycine
relates
polypeptides
useful
biological
activity
mammal
comprise
related
bradykinin
residues
specific
acids
chain
achiral
analogues
potent
agonist
antagonist
pharmacological
properties
depending
structure
preferred
-bradykinin
amino acid
amino acids
acid residues
acid residue
/530/