Methods for chromosome-specific staining
Patent
·
OSTI ID:870054
- Livermore, CA
- Walnut Creek, CA
Methods and compositions for chromosome-specific staining are provided. Compositions comprise heterogenous mixtures of labeled nucleic acid fragments having substantially complementary base sequences to unique sequence regions of the chromosomal DNA for which their associated staining reagent is specific. Methods include methods for making the chromosome-specific staining compositions of the invention, and methods for applying the staining compositions to chromosomes.
- Research Organization:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA
- DOE Contract Number:
- W-7405-ENG-48
- Assignee:
- Regents Of Univ. Of California (Oakland, CA)
- Patent Number(s):
- US 5447841
- OSTI ID:
- 870054
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
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acid
acid fragment
applying
associated
base
base sequence
base sequences
chromosomal
chromosomal dna
chromosome-specific
chromosome-specific staining
chromosomes
complementary
complementary base
compositions
compositions comprise
comprise
dna
fragments
heterogenous
labeled
methods
mixtures
nucleic
nucleic acid
provided
reagent
regions
sequence
sequences
specific
staining
staining reagent
substantially
substantially complementary
unique
acid
acid fragment
applying
associated
base
base sequence
base sequences
chromosomal
chromosomal dna
chromosome-specific
chromosome-specific staining
chromosomes
complementary
complementary base
compositions
compositions comprise
comprise
dna
fragments
heterogenous
labeled
methods
mixtures
nucleic
nucleic acid
provided
reagent
regions
sequence
sequences
specific
staining
staining reagent
substantially
substantially complementary
unique