Substituted 6-nitroquipazines, methods of preparation, and methods of use

Patent · Fri Dec 31 23:00:00 EST 1993

OSTI ID:869645

Biegon, Anat ^[1]; Taylor, Scott E ^[2]; Enas, Joel D ^[3]

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1. Rohovot, IL
2. Pleasant Hill, CA
3. Pittsburg, CA

Disclosed is a substituted 6-nitroquipazine of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are each selected from the group consisting of H, Fl, CL, Br, I, CF.sub.3, CH.sub.2 CH.sub.2 F, CH.sub.3, CH.sub.2 CH.sub.3, and --CH(CH.sub.3).sub.2, and wherein one of R.sub.1, R.sub.2, R.sub.3, and R.sub.4 is other than H. Also disclosed is a method for measurement of serotonin uptake sites in a sample, in which a radioligand is incubated with a sample and then the radioactivity of the radioligand bound to the sample is determined, utilizing a radio labeled substituted 6-nitroquipazine as the radioligand. Also disclosed is a method of manufacture and method of use.

• Research Organization: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA
• DOE Contract Number: AC03-76SF00098
• Assignee: Regents, University of California (Oakland, CA)
• Patent Number(s): US 5372813
• OSTI ID: 869645
• Country of Publication: United States
• Language: English

Related Subjects

--chchsub3sub2
/424/436/999/
6-nitroquipazine
6-nitroquipazines
bound
br
cfsub3
chsub2
chsub3
consisting
determined
disclosed
fl
formula
incubated
labeled
manufacture
measurement
method
methods
preparation
radio
radio labeled
radioactivity
radioligand
rsub1
rsub2
rsub3
rsub4
sample
selected
serotonin
serotonin uptake sites
sites
str1
substituted
uptake
utilizing