Catalytic and reactive polypeptides and methods for their preparation and use

Patent · Sat Jan 01 00:00:00 EST 1994

OSTI ID:869318

Schultz, Peter ^[1]

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1. Oakland, CA

Catalytic and reactive polypeptides include a binding site specific for a reactant or reactive intermediate involved in a chemical reaction of interest. The polypeptides further include at least one active functionality proximate the binding site, where the active functionality is capable of catalyzing or chemically participating in the chemical reaction in such a way that the reaction rate is enhanced. Methods for preparing the catalytic peptides include chemical synthesis, site-directed mutagenesis of antibody and enzyme genes, covalent attachment of the functionalities through particular amino acid side chains, and the like. This invention was made with Government support under Grant Contract No. AI-24695, awarded by the Department of health and Human Services, and under Grant Contract No. N 00014-87-K-0256, awarded by the Office of Naval Research. The Government has certain rights in this invention.

• Research Organization: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
• DOE Contract Number: C87-101226
• Assignee: Regents of University of California (Oakland, CA)
• Patent Number(s): US 5314817
• OSTI ID: 869318
• Country of Publication: United States
• Language: English

Related Subjects

catalytic
reactive
polypeptides
methods
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binding
site
specific
reactant
intermediate
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chemical
reaction
active
functionality
proximate
capable
catalyzing
chemically
participating
rate
enhanced
preparing
peptides
synthesis
site-directed
mutagenesis
antibody
enzyme
genes
covalent
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particular
amino
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government
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grant
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awarded
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health
human
services
00014-87-k-0256
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naval
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reactive polypeptides
chemical synthesis
active functionality
reaction rate
binding site
amino acid
chemical reaction
government support
reactive intermediate
site specific
functionality proximate
human services
intermediate involved
active poly
active polypeptide
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