Porphyrins for boron neutron capture therapy

Patent · 31 December 1989

OSTI ID:867537

Miura, Michiko ^[1]; Gabel, Detlef ^[2]

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1. Center Moriches, NY
2. Bremen, DE

Novel compounds for treatment of brain tumors in Boron Neutron Capture Therapy are disclosed. A method for preparing the compounds as well as pharmaceutical compositions containing said compounds are also disclosed. The compounds are water soluble, non-toxic and non-labile boronated porphyrins which show significant uptake and retention in tumors.

• Research Organization: ASSOC UNIVERSITIES INC
• DOE Contract Number: AC02-76CH00016
• Assignee: United States of America as represented by United States (Washington, DC)
• Patent Number(s): US 4959356
• OSTI ID: 867537
• Country of Publication: United States
• Language: English

Related Subjects

/424/999/
boron
boron neutron
boronated
boronated porphyrins
brain
brain tumors
capture
capture therapy
compositions
compositions contain
compositions containing
compounds
containing
disclosed
method
neutron
neutron capture
non-labile
non-toxic
novel
novel compound
novel compounds
pharmaceutical
pharmaceutical composition
pharmaceutical compositions
porphyrins
preparing
retention
significant
soluble
therapy
treatment
tumors
uptake
water
water soluble