Polarization transfer NMR imaging

Patent · Mon Jan 01 04:00:00 EST 1990

OSTI ID:867365

Sillerud, Laurel O ^[1]; van Hulsteyn, David B ^[2]

---

1. Los Alamos, NM
2. Santa Fe, NM

A nuclear magnetic resonance (NMR) image is obtained with spatial information modulated by chemical information. The modulation is obtained through polarization transfer from a first element representing the desired chemical, or functional, information, which is covalently bonded and spin-spin coupled with a second element effective to provide the imaging data. First and second rf pulses are provided at first and second frequencies for exciting the imaging and functional elements, with imaging gradients applied therebetween to spatially separate the nuclei response for imaging. The second rf pulse is applied at a time after the first pulse which is the inverse of the spin coupling constant to select the transfer element nuclei which are spin coupled to the functional element nuclei for imaging. In a particular application, compounds such as glucose, lactate, or lactose, can be labeled with .sup.13 C and metabolic processes involving the compounds can be imaged with the sensitivity of .sup.1 H and the selectivity of .sup.13 C.

• Research Organization: Los Alamos National Laboratory (LANL), Los Alamos, NM
• DOE Contract Number: W-7405-ENG-36
• Assignee: United States of America as represented by United States (Washington, DC)
• Patent Number(s): US 4922203
• OSTI ID: 867365
• Country of Publication: United States
• Language: English

Related Subjects

/324/
13
application
applied
bonded
chemical
chemical information
compounds
constant
coupled
coupling
covalently
covalently bonded
data
desired
desired chemical
effective
element
elements
exciting
frequencies
functional
functional elements
glucose
gradients
image
imaged
imaging
information
inverse
involving
labeled
lactate
lactose
magnetic
magnetic resonance
metabolic
modulated
modulation
nmr
nmr imaging
nuclear
nuclear magnetic
nuclei
obtained
particular
particular application
polarization
polarization transfer
processes
processes involving
provide
provided
pulse
pulses
representing
resonance
response
rf
rf pulse
rf pulses
select
selectivity
sensitivity
separate
spatial
spatial information
spatially
spatially separate
spin
spin-spin
therebetween
time
transfer