No-carrier-added [1.sup.11 c]putrescine
Patent
·
OSTI ID:867138
- Baltimore, MD
- Bellport, NY
- Setauket, NY
The invention relates to a new radiolabeled imaging agent, no-carrier-added [1-.sup.11 C]putrescine, and to the use of this very pure material as a radiotracer with positron emission tomography for imaging brain tumors. The invention further relates to the synthesis of no-carrier-added [1-.sup.11 C]putrescine based on the Michael addition of potassium .sup.11 C-labeled cyanide to acrylonitrile followed by reduction of the .sup.11 C-labeled dinitrile. The new method is rapid and efficient and provides radiotracer with a specific activity greater than 1.4 curies per millimol and in a purity greater than 95%.
- Research Organization:
- Associated Universities, Inc., Upton, NY (United States)
- DOE Contract Number:
- AC02-76CH00016
- Assignee:
- United States of America as Represented by United States (Washington, DC)
- Patent Number(s):
- US 4874600
- OSTI ID:
- 867138
- Country of Publication:
- United States
- Language:
- English
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