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Title: Precursors to radiopharmaceutical agents for tissue imaging

Abstract

A class of radiolabeled compounds to be used in tissue imaging that exhibits rapid brain uptake, good brain:blood radioactivity ratios, and long retention times. The imaging agents are more specifically radioiodinated aromatic amines attached to dihydropyridine carriers, that exhibit heart as well as brain specificity. In addition to the radiolabeled compounds, classes of compounds are also described that are used as precursors and intermediates in the preparation of the imaging agents.

Inventors:
 [1]
  1. Oak Ridge, TN
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
OSTI Identifier:
866689
Patent Number(s):
US 4764598
Assignee:
United States of America as represented by Department of Energy (Washington, DC)
DOE Contract Number:  
W-7405-ENG-26
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
precursors; radiopharmaceutical; agents; tissue; imaging; radiolabeled; compounds; exhibits; rapid; brain; uptake; blood; radioactivity; ratios; retention; times; specifically; radioiodinated; aromatic; amines; attached; dihydropyridine; carriers; exhibit; heart; specificity; addition; described; intermediates; preparation; aromatic amines; imaging agents; labeled compounds; retention time; imaging agent; tissue imaging; rapid brain; radiolabeled compound; aromatic amine; /999/

Citation Formats

Srivastava, Prem C, and Knapp, Jr., Furn F. Precursors to radiopharmaceutical agents for tissue imaging. United States: N. p., 1988. Web.
Srivastava, Prem C, & Knapp, Jr., Furn F. Precursors to radiopharmaceutical agents for tissue imaging. United States.
Srivastava, Prem C, and Knapp, Jr., Furn F. Fri . "Precursors to radiopharmaceutical agents for tissue imaging". United States. https://www.osti.gov/servlets/purl/866689.
@article{osti_866689,
title = {Precursors to radiopharmaceutical agents for tissue imaging},
author = {Srivastava, Prem C and Knapp, Jr., Furn F.},
abstractNote = {A class of radiolabeled compounds to be used in tissue imaging that exhibits rapid brain uptake, good brain:blood radioactivity ratios, and long retention times. The imaging agents are more specifically radioiodinated aromatic amines attached to dihydropyridine carriers, that exhibit heart as well as brain specificity. In addition to the radiolabeled compounds, classes of compounds are also described that are used as precursors and intermediates in the preparation of the imaging agents.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1988},
month = {1}
}

Patent:

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