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Precursors to radiopharmaceutical agents for tissue imaging

Patent ·
OSTI ID:866689
 [1]
  1. Oak Ridge, TN
+ Show Author Affiliations
A class of radiolabeled compounds to be used in tissue imaging that exhibits rapid brain uptake, good brain:blood radioactivity ratios, and long retention times. The imaging agents are more specifically radioiodinated aromatic amines attached to dihydropyridine carriers, that exhibit heart as well as brain specificity. In addition to the radiolabeled compounds, classes of compounds are also described that are used as precursors and intermediates in the preparation of the imaging agents.
Research Organization:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN
DOE Contract Number:
W-7405-ENG-26
Assignee:
United States of America as represented by Department of Energy (Washington, DC)
Patent Number(s):
US 4764598
OSTI ID:
866689
Country of Publication:
United States
Language:
English

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Related Subjects

/999/
addition
agents
amines
aromatic
aromatic amine
aromatic amines
attached
blood
brain
carriers
compounds
described
dihydropyridine
exhibit
exhibits
heart
imaging
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imaging agents
intermediates
labeled compounds
precursors
preparation
radioactivity
radioiodinated
radiolabeled
radiolabeled compound
radiopharmaceutical
rapid
rapid brain
ratios
retention
retention time
specifically
specificity
times
tissue
tissue imaging
uptake