Nose-only exposure system

Patent · Fri Jan 01 04:00:00 EST 1988

OSTI ID:866478

Cannon, William C ^[1]; Bass, Edward W ^[2]

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1. Richland, WA
2. Kennewick, WA

An exposure system for supplying a gaseous material, i.e. an aerosol, gas or a vapor, directly to the noses of experimental animals includes concentric vertical inner and outer manifolds. The outer manifold connects with the necks of a large number of bottles in which the animals are confined with their noses adjacent the bottle necks. Readily detachable small tubes communicate with the inner manifold and extend to the necks of the bottles. The upper end of the outer manifold and the lower end of the inner manifold are closed. Gaseous material is supplied to the upper end of the inner manifold, flows through the small tubes to points adjacent the noses of the individual animals, then is drawn out through the bottom of the outer manifold. The bottles are readily removable and the device can be disassembled, e.g., for cleaning, by removing the bottles, removing the small tubes, and lifting the inner manifold from the outer manifold. The bottles are supported by engagement of their necks with the outer manifold supplemented, if additional support is required, by individual wire cradles. The outer ends of the bottles are closed by plugs, through which pass metal tubes which receive the tails of the animals (usually rodents) and which serve to dissipate body heat. The entire device is mounted for rotation on turntable bearings.

• Research Organization: BATTELLE MEMORIAL INSTITUTE
• DOE Contract Number: AC06-76RL01830
• Assignee: Battelle Memorial Institute (Columbus, OH)
• Patent Number(s): US 4721060
• OSTI ID: 866478
• Country of Publication: United States
• Language: English

Related Subjects

/119/128/
additional
adjacent
aerosol
animals
bearings
bottle
bottles
bottom
cleaning
closed
communicate
concentric
confined
connects
cradles
detachable
device
directly
disassembled
dissipate
drawn
engagement
entire
entire device
experimental
experimental animals
exposure
extend
flows
gas
gaseous
gaseous material
heat
individual
inner
lifting
manifold
manifold connects
manifolds
material
metal
metal tube
metal tubes
mounted
necks
nose-only
nose-only exposure
noses
outer
outer manifold
outer manifolds
pass
plugs
readily
readily removable
receive
removable
removing
required
rodents
rotation
serve
supplemented
supplied
supplying
support
supported
tails
tubes
turntable
upper
vapor
vertical
wire