Macrocyclic bifunctional chelating agents

Patent · Thu Jan 01 00:00:00 EST 1987

OSTI ID:866304

Meares, Claude F ^[1]; DeNardo, Sally J ^[2]; Cole, William C ^[3]; Mol, Min K ^[1]

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1. Davis, CA
2. El Macero, CA
3. Houston, TX

A copper chelate conjugate which is stable in human serum. The conjugate includes the copper chelate of a cyclic tetraaza di-, tri-, or tetra-acetic acid, a linker attached at one linker end to a ring carbon of the chelate, and a biomolecule joined at the other end of the linker. The conjugate, or the linker-copper chelate compound used in forming the conjugate, are designed for use in diagnostic and therapeutic applications which involve Cu(II) localization via the systemic route.

• Research Organization: NATIONAL BUREAU OF STANDARDS
• DOE Contract Number: AT03-82ER60056
• Assignee: University of California (Berkeley, CA)
• Patent Number(s): US 4678667
• OSTI ID: 866304
• Country of Publication: United States
• Language: English

Related Subjects

macrocyclic
bifunctional
chelating
agents
copper
chelate
conjugate
stable
human
serum
cyclic
tetraaza
di-
tri-
tetra-acetic
acid
linker
attached
carbon
biomolecule
joined
linker-copper
compound
forming
designed
diagnostic
therapeutic
applications
involve
cu
ii
localization
via
systemic
route
bifunctional chelating
acetic acid
chelating agents
chelating agent
human serum
copper chelate
/424/999/