Macrocyclic bifunctional chelating agents

Patent · 01 January 1987

OSTI ID:866304

Meares, Claude F ^[1]; DeNardo, Sally J ^[2]; Cole, William C ^[3]; Mol, Min K ^[1]

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1. Davis, CA
2. El Macero, CA
3. Houston, TX

A copper chelate conjugate which is stable in human serum. The conjugate includes the copper chelate of a cyclic tetraaza di-, tri-, or tetra-acetic acid, a linker attached at one linker end to a ring carbon of the chelate, and a biomolecule joined at the other end of the linker. The conjugate, or the linker-copper chelate compound used in forming the conjugate, are designed for use in diagnostic and therapeutic applications which involve Cu(II) localization via the systemic route.

• Research Organization: NATIONAL BUREAU OF STANDARDS
• DOE Contract Number: AT03-82ER60056
• Assignee: University of California (Berkeley, CA)
• Patent Number(s): US 4678667
• OSTI ID: 866304
• Country of Publication: United States
• Language: English

Related Subjects

/424/999/
acetic acid
acid
agents
applications
attached
bifunctional
bifunctional chelating
biomolecule
carbon
chelate
chelating
chelating agent
chelating agents
compound
conjugate
copper
copper chelate
cu
cyclic
designed
di-
diagnostic
forming
human
human serum
ii
involve
joined
linker
linker-copper
localization
macrocyclic
route
serum
stable
systemic
tetra-acetic
tetraaza
therapeutic
tri-
via