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Affinity labelling enzymes with esters of aromatic sulfonic acids

Patent ·
OSTI ID:862736

Novel esters of aromatic sulfonic acids are disclosed. The specific esters are nitrophenyl p- and m-amidinophenylmethanesulfonate. Also disclosed is a method for specific inactivation of the enzyme, thrombin, employing nitrophenyl p-amidinophenylmethanesulfonate.

Research Organization:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Organization:
US Atomic Energy Commission (AEC)
Assignee:
United States of America (Washington, DC)
Patent Number(s):
4,001,087
Application Number:
05/629133
OSTI ID:
862736
Country of Publication:
United States
Language:
English