Quantum Dots as Cellular Probes
Robust and bright light emitters, semiconductor nanocrystals[quantum dots (QDs)] have been adopted as a new class of fluorescent labels. Six years after the first experiments of their uses in biological applications, there have been dramatic improvements in understanding surface chemistry, biocompatibility, and targeting specificity. Many studies have shown the great potential of using quantum dots as new probes in vitro and in vivo. This review summarizes the recent advances of quantum dot usage at the cellular level, including immunolabeling, cell tracking, in situ hybridization, FRET, in vivo imaging, and other related technologies. Limitations and potential future uses of quantum dot probes are also discussed.
- Research Organization:
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Sponsoring Organization:
- USDOE Director, Office of Science; National Institutes ofHealth
- DOE Contract Number:
- DE-AC02-05CH11231; NIH:0980GFD623
- OSTI ID:
- 862088
- Report Number(s):
- LBNL-59120; R&D Project: M50013; BnR: 600305000; TRN: US200601%%312
- Journal Information:
- Annual Review of Biomedical Engineering, Vol. 7; Related Information: Journal Publication Date: August 2005
- Country of Publication:
- United States
- Language:
- English
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