Dual-Modality PET/Ultrasound imaging of the Prostate

Conference · Fri Nov 11 04:00:00 EST 2005

OSTI ID:862086

Huber, Jennifer S; Moses, William W; Pouliot, Jean; Hsu, I C

Functional imaging with positron emission tomography (PET)will detect malignant tumors in the prostate and/or prostate bed, as well as possibly help determine tumor ''aggressiveness''. However, the relative uptake in a prostate tumor can be so great that few other anatomical landmarks are visible in a PET image. Ultrasound imaging with a transrectal probe provides anatomical detail in the prostate region that can be co-registered with the sensitive functional information from the PET imaging. Imaging the prostate with both PET and transrectal ultrasound (TRUS) will help determine the location of any cancer within the prostate region. This dual-modality imaging should help provide better detection and treatment of prostate cancer. LBNL has built a high performance positron emission tomograph optimized to image the prostate.Compared to a standard whole-body PET camera, our prostate-optimized PET camera has the same sensitivity and resolution, less backgrounds and lower cost. We plan to develop the hardware and software tools needed for a validated dual PET/TRUS prostate imaging system. We also plan to develop dual prostate imaging with PET and external transabdominal ultrasound, in case the TRUS system is too uncomfortable for some patients. We present the design and intended clinical uses for these dual imaging systems.

• Research Organization: Ernest Orlando Lawrence Berkeley NationalLaboratory, Berkeley, CA (US)
• Sponsoring Organization: USDOE Director. Office of Science. Office of Biological andEnvironmental Research. Medical Science Division; US Department ofDefense Grant DAMD17-02-1-0081, National Institute for Biomedical Imagingand Bioengineering Grants R01-EB00194 and R01-HL-071253
• DOE Contract Number: AC02-05CH11231
• OSTI ID: 862086
• Report Number(s): LBNL--59114; BnR: KP1401030
• Country of Publication: United States
• Language: English

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DESIGN
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FUNCTIONALS
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PATIENTS
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POSITRONS
PROBES
PROSTATE
RESOLUTION
SENSITIVITY
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