Comparison of 3D Maximum A Posteriori and Filtered Backprojection algorithms for high resolution animal imaging in microPET

Journal Article · Sat Jan 01 04:00:00 EST 2000

OSTI ID:843118

Chatziioannou, A ^[1]; Qi, J; Moore, A; Annala, A; Nguyen, K; Leahy, R M; Cherry, S R

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1. LBNL Library

We have evaluated the performance of two three dimensional reconstruction algorithms with data acquired from microPET, a high resolution tomograph dedicated to small animal imaging. The first was a linear filtered-backprojection algorithm (FBP) with reprojection of the missing data and the second was a statistical maximum-aposteriori probability algorithm (MAP). The two algorithms were evaluated in terms of their resolution performance, both in phantoms and in vivo. Sixty independent realizations of a phantom simulating the brain of a baby monkey were acquired, each containing 3 million counts. Each of these realizations was reconstructed independently with both algorithms. The ensemble of the sixty reconstructed realizations was used to estimate the standard deviation as a measure of the noise for each reconstruction algorithm. More detail was recovered in the MAP reconstruction without an increase in noise relative to FBP. Studies in a simple cylindrical compartment phantom demonstrated improved recovery of known activity ratios with MAP. Finally in vivo studies also demonstrated a clear improvement in spatial resolution using the MAP algorithm. The quantitative accuracy of the MAP reconstruction was also evaluated by comparison with autoradiography and direct well counting of tissue samples and was shown to be superior.

• Research Organization: Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, CA (US)
• Sponsoring Organization: USDOE Director. Office of Science; National Cancer Institute Grant R01 CA69370 and R01 CA59794
• DOE Contract Number: AC03-76SF00098
• OSTI ID: 843118
• Report Number(s): LBNL--45516
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ACCURACY
ALGORITHMS
ANIMALS
AUTORADIOGRAPHY
BRAIN
COMPARTMENTS
IN VIVO
MONKEYS
PERFORMANCE
PHANTOMS
PROBABILITY
Positron Emission Tomography image reconstruction small animal imaging.
RESOLUTION
SPATIAL RESOLUTION