Aneuploidy involving chromosome 1 in failed-fertilized human oocytes is unrelated to maternal age

Journal Article · Sat Dec 04 04:00:00 EST 2004 · Journal of Assisted Reproduction and Genetics

OSTI ID:843014

Weier, Jingly Fung ^[1]; Weier, Heinz-Ulrich G; Nureddin, Aida; Pedersen, Roger A; Racowsky, Catherine

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1. LBNL Library

Purpose: To study whether maternal meiotic errors in failed-fertilized oocytes involving chromosome 1 occur at frequencies similar to those involving other autosomes, and whether their frequency is affected by maternal age. Methods: Using fluorescence in situ hybridization (FISH), frequencies of aneusomy and chromatid pre-division involving chromosomes 1, 16, 18, and 21 were determined for 273 failed-fertilized oocytes. Results: The aneuploidy rate for chromosome 1 was 15.8 percent, and was neither age-dependent nor significantly different from that for chromosomes 16,18 or 21. Only chromosome 16 exhibited an age-dependent increase in aneusomy rates. The frequency of chromatid pre-division was lower for chromosome 1 than for chromosome 18 (11.9 percent vs. 25.4 percent; P=0.01), but not different from that for chromosomes 16 or 21. Conclusion: Aneuploidy involving chromosome 1 in failed-fertilized oocytes is unrelated to maternal age and occurs at a frequency similar to that for chromosomes 16, 18 and 21.

• Research Organization: Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, CA (US)
• Sponsoring Organization: USDOE Director. Office of Science, UC BioSTAR Program, UCSF/Stanford Enterprise Fund, OB/Gyn Invitro Fertilisation Discretionary Funds; Industry Contract BG02-362(00)
• DOE Contract Number: AC03-76SF00098
• OSTI ID: 843014
• Report Number(s): LBNL--58557
• Journal Information: Journal of Assisted Reproduction and Genetics, Journal Name: Journal of Assisted Reproduction and Genetics Journal Issue: 7 Vol. 22
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
60 APPLIED LIFE SCIENCES
ANEUPLOIDY
CHROMATIDS
CHROMOSOMES
FLUORESCENCE
IN-SITU HYBRIDIZATION
OOCYTES
chromosomes aneuploidy failed-fertilized oocytes maternal age